Dysfunctional mitochondrial quality control (MQC) is implicated in the pathogenesis of
Parkinson's disease (PD). The improper selection of mitochondria for mitophagy increases …

Parkinson's disease (PD) is a movement disorder characterized by the progressive
degeneration of dopaminergic neurons resulting in dopamine deficiency in the striatum …

Many lines of evidence have indicated the therapeutic potential of rescuing mitochondrial
integrity by targeting specific mitochondrial quality control pathways in neurodegenerative …

The loss of dopaminergic (DA) neurons in the substantia nigra leads to a progressive, long-
term decline of movement and other non-motor deficits. The symptoms of Parkinson's …

In recent years, several important advances have been made in our understanding of the
pathways that lead to cell dysfunction and death in Parkinson's disease (PD) and …

Mitochondria, the powerhouse of the neural cells in the brain, are also the seat of certain
essential gene signaling pathways that control neuronal functions. Deterioration of …

Parkinson's disease (PD) is the second most common rapidly progressive
neurodegenerative disease and has serious health and socio-economic consequences …

The underlying pathophysiology of Parkinson's disease is complex, but mitochondrial
dysfunction has an established and prominent role. This is supported by an already large …

Mitochondrial health is based on a delicate balance of specific mitochondrial functions (eg
metabolism, signaling, dynamics) that are impaired in neurodegenerative diseases …

The human brain has high energetic expenses and consumes over 20% of total oxygen
metabolism. Abnormal brain energy homeostasis leads to various brain diseases. Among …