Aging is a progressive loss of physiological function that increases risk of disease and
death. Among the many factors that contribute to human aging, mitochondrial dysfunction …

Mitochondrial dysfunction has been reported in most neurodegenerative diseases. These
anomalies include bioenergetic defect, respiratory chain-induced oxidative stress, defects of …

Over two centuries ago James Parkinson published “An Essay on the Shaking Palsy”
summarizing his experience with neural pathology now known as Parkinson's disease …

Decrease in mitochondrial energy-transducing capacity is a feature of the aging process that
accompanies redox alterations, such as increased generation of mitochondrial oxidants …

Skeletal muscle mitochondrial degeneration is a hallmark of insulin resistance/obesity
marked by lost function, enhanced ROS emission, and altered morphology which may be …

Mitochondria function differently in aged brains than they do in young brains. Consistently
reported changes include reduced electron transport chain (ETC) enzyme activities, reduced …

The decline of nicotinamide adenine dinucleotide (NAD+) levels is a hallmark of aging in
multiple organisms and tissues, including the human brain. Hence, agents that increase …

Recent findings from genetic studies suggest that defective mitochondrial quality control may
play an important role in the development of Parkinson's disease (PD). Such defects may …

As the principal energy-producing organelles of the cell, mitochondria support numerous
biological processes related to metabolism, growth, and regeneration in skeletal muscle …

Mitochondrial dysfunction is a hallmark of Parkinson's disease (PD). Astrocytes are the most
abundant glial cell type in the brain and are thought to play a pivotal role in the progression …