Parkinson's disease (PD) is one of the most common neurodegenerative movement disorder
characterized by preferential loss of dopaminergic neurons of the substantia nigra pars …

Significance: Several genetic causes of familial Parkinson's disease (PD) have now been
identified and include mutations of genes encoding mitochondrial proteins. Mitochondrial …

As neurons are highly energy-demanding cell, increasing evidence suggests that
mitochondria play a large role in several age-related neurodegenerative diseases. Synaptic …

Mitochondria are the foremost producers of the cellular energy currency ATP. They are also
a significant source of reactive oxygen species and an important buffer of intracellular …

Nicotinamide adenine dinucleotide (NAD+) is a central metabolic cofactor in eukaryotic cells
that plays a critical role in regulating cellular metabolism and energy homeostasis. NAD+ in …

Mitochondrial dysfunction and oxidative stress are considered among the main molecular
mechanisms implicated in Parkinson's disease (PD) pathogenesis. Here, we focus on the …

Mitochondrial dysfunction is not only a hallmark of rare inherited mitochondrial disorders but
also implicated in age-related diseases, including those that affect the metabolic and …

The selective cell loss in the ventral component of the substantia nigra pars compacta and
the presence of alpha-synuclein (α-syn)-rich intraneuronal inclusions called Lewy bodies …

Mitochondria have a crucial role in the supply of energy to the brain. Mitochondrial
alterations can lead to detrimental consequences on the function of brain cells and are …

Progressive mitochondrial dysfunction is linked with the onset of many age‐related
pathologies and neurological disorders. Mitochondrial damage can come in many forms and …