It remains a challenge to predict whether a new drug candidate will have undesirable side
effects. Many biologically active molecules, including drugs and drug-leads, are amphiphiles …

It remains a challenge to predict whether a new drug candidate will have undesirable side
effects. Many biologically active molecules, including drugs and drug-leads, are amphiphiles …

It remains a challenge to predict whether or not a new drug candidate will have undesirable
side-effects in the clinic. Many biologically active molecules, including drugs and drug-leads …

Cell membranes are mosaics comprised of lipid bilayers and a multitude of embedded
transmembrane proteins. Because membrane proteins undergo conformational changes …

A perennial problem encountered when using small molecules (drugs) to manipulate cell or
protein function is to assess whether observed changes in function result from specific …

Partitioning of bioactive molecules, including drugs, into cell membranes may produce
indiscriminate changes in membrane protein function. As a guide to safe drug development …

Many drugs and other small molecules used to modulate biological function are amphiphiles
that adsorb at the bilayer/solution interface and thereby alter lipid bilayer properties. This is …

Poly-unsaturated fatty acids (PUFAs) alter the function of many membrane proteins, whereas
monounsatured fatty acids generally are inert. We previously showed that docosahexaenoic …

It is important to realize that a lipid bilayer membrane is not just a homogeneous thin slap of
a dielectric medium immersed in water but that the bilayer is a highly stratified structure with …

Many drugs and other small molecules used to modulate biological function are amphiphiles
that adsorb at the bilayer/solution interface and thereby alter lipid bilayer properties. This is …