The models are an Scn1a+/-knockout mouse developed in the laboratory of Dr. William
Catterall (4) and a mouse engineered with the Dravet syndrome mutation SCN1A-R1407X …

Dravet syndrome is an intractable pediatric epilepsy associated with SCN1A mutations. In
addition to having a large seizure burden and a reduced lifespan, patients with Dravet …

Dravet syndrome is a rare, severe, infancy-onset epileptic encephalopathy associated with a
high premature mortality. In most patients, Dravet syndrome is caused by a heterozygous …

Many disease‐relevant phenotypes modeled in inbred mice have been shown to be strain‐
dependent, indicating the important influence of genetic background on disease …

Dravet Syndrome–It's Not Only Interneurons channels, possibly Nav1. 2 or Nav1. 6, for firing.
Based on this model, it was hypothesized that pathophysiology in DS is due to dysfunctional …

Objective Epilepsy is a common neurological disorder that affects 1% of the population.
Approximately, 30% of individuals with epilepsy are refractory to treatment, highlighting the …

Abstract Objective Dravet syndrome (Dravet) is a severe childhood epileptic
encephalopathy. The disease begins with a febrile stage, characterized by febrile seizures …

Heterozygous loss-of-function SCN1A mutations cause Dravet syndrome, an epileptic
encephalopathy of infancy that exhibits variable clinical severity. We utilized a heterozygous …

Epilepsy is a common neurological disorder affecting approximately 1% of the population.
Mutations in voltage‐gated sodium channels are responsible for several monogenic …

Dravet syndrome (DS) is a debilitating infantile epileptic encephalopathy characterized by
seizures induced by high body temperature (hyperthermia), sudden unexpected death in …