Somatic rearrangements resulting in genomic structural variation drive malignant
phenotypes by altering the expression or function of cancer genes. Pan-cancer studies have …

Next-generation sequencing (NGS) has enabled the comprehensive and precise
identification of many somatic structural mutations in cancer. Analyses integrating point …

With the advent of next-generation sequencing technologies, we have witnessed a rapid
pace of discovery of new patterns of somatic structural variation in cancer genomes, and an …

Structural variants (SVs) represent a major source of aberration in tumour genomes. Given
the diversity in the size and type of SVs present in tumours, the accurate detection and …

Tumor genomes are mosaics of somatic structural variants (SVs) that may contribute to the
activation of oncogenes or inactivation of tumor suppressors, for example, by altering gene …

Genetic abnormalities are present in all tumor types, although the frequency and type can
vary. Chromosome abnormalities include highly aberrant structures, particularly …

A systematic cataloging of genes affected by genomic rearrangement, using multiple patient
cohorts and cancer types, can provide insight into cancer-relevant alterations outside of …

The collective somatic mutations observed in a cancer are the outcome of multiple
mutagenic processes that have been operative over the lifetime of a patient. Each process …

Structural variations (SVs) affect more of the cancer genome than any other type of somatic
genetic alteration but difficulties in detecting and interpreting them have limited our …

The impact of somatic structural variants (SVs) on gene expression in cancer is largely
unknown. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes …