To a large extent, cancer conforms to evolutionary rules defined by the rates at which clones
mutate, adapt and grow. Next-generation sequencing has provided a snapshot of the …

Oncogenesis is a pathologic process driven by genomic aberrations, including changes in
nucleotide sequences. The majority of these mutational events fall into two broad categories …

Next-generation sequencing has allowed identification of millions of somatic mutations and
epigenetic changes in cancer cells. A key challenge in interpreting cancer genomes and …

Much remains unknown about the progression and heterogeneity of mutational processes in
different cancers and their diagnostic and clinical potential. A growing body of evidence …

Background The identification of mutations that play a causal role in tumour development, so
called “driver” mutations, is of critical importance for understanding how cancers form and …

Abstract Analysis of spatial and temporal genetic heterogeneity in human cancers has
revealed that somatic cancer evolution in most cancers is not a simple linear process …

Each individual cell within a human body acquires a certain number of somatic mutations
during a course of its lifetime. These mutations originate from a wide spectra of both …

Mutational signatures are patterns of mutations that arise during tumorigenesis. We present
an enhanced, practical framework for mutational signature analyses. Applying these …

Background Large-scale tumor sequencing projects are now underway to identify genetic
mutations that drive tumor initiation and development. Most studies take a gene-based …

Tumor genomes are generally thought to evolve through a gradual accumulation of
mutations, but the observation that extraordinarily complex rearrangements can arise …