Volumetric MRI demonstrates atrophy of the olfactory cortex in AD

M Al-Otaibi, M Lessard-Beaudoin… - Current Alzheimer …, 2020 - ingentaconnect.com
Objective: Alzheimer disease (AD) is a chronic neurodegenerative disorder that affects
millions of individuals worldwide. Symptoms include memory dysfunction and deficits in …

Olfactory cortex degeneration in Alzheimer's disease and mild cognitive impairment

MM Vasavada, J Wang, PJ Eslinger… - Journal of …, 2015 - content.iospress.com
Background: Olfactory deficits are prevalent in patients with Alzheimer's disease (AD) and
mild cognitive impairment (MCI). These symptoms precede clinical onset of cognitive and …

Entorhinal cortex and parahippocampus volume reductions impact olfactory decline in aged subjects

N Iizuka, Y Masaoka, S Kubota, H Sugiyama… - Brain and …, 2021 - Wiley Online Library
Introduction Pathological abnormalities first appear in the medial temporal regions including
entorhinal cortex and parahippocampus in patients with Alzheimer's disease. Previous …

Magnetic resonance imaging findings among individuals with olfactory and cognitive impairment

JS Yi, N Hura, CR Roxbury, SY Lin - The Laryngoscope, 2022 - Wiley Online Library
Objectives The underlying mechanism of the association between olfactory impairment and
dementia may be explained by neurodegenerative changes detected on magnetic …

MRI-derived atrophy of the olfactory bulb and tract in mild cognitive impairment and Alzheimer's disease

PA Thomann, V Dos Santos, U Seidl… - Journal of …, 2009 - content.iospress.com
There is increasing histopathological evidence that the olfactory bulb and tract (OBT) is a
primary focus of neurodegenerative changes in Alzheimer's disease (AD). Correspondingly …

Odor identification deficit in mild cognitive impairment and Alzheimer's disease is associated with hippocampal and deep gray matter atrophy

J Hagemeier, MR Woodward, UA Rafique… - Psychiatry Research …, 2016 - Elsevier
Even in early stages, Alzheimer's disease (AD) is associated with olfactory deficit. We
assess the association of volumetric differences in subcortical deep gray matter (DGM) …

Central olfactory dysfunction in Alzheimer's disease and mild cognitive impairment: a functional MRI study

MM Vasavada, B Martinez, J Wang… - Journal of …, 2017 - content.iospress.com
Background: Olfactory deficits are present in early Alzheimer's disease (AD) and mild
cognitively impaired (MCI) patients. However, whether these deficits are due to dysfunction …

Olfactory identification deficit predicts white matter tract impairment in Alzheimer's disease

MR Woodward, MG Dwyer, N Bergsland… - Psychiatry Research …, 2017 - Elsevier
Olfactory identification deficit (OID) has been associated with both aging and Alzheimer's
disease (AD). In the context of an amnestic disorders, OID predicts conversion to AD …

Olfactory deficit: a potential functional marker across the Alzheimer's disease continuum

D Liu, J Lu, L Wei, M Yao, H Yang, P Lv… - Frontiers in …, 2024 - frontiersin.org
Alzheimer's disease (AD) is a prevalent form of dementia that affects an estimated 32 million
individuals globally. Identifying early indicators is vital for screening at-risk populations and …

Left hippocampal volume loss in Alzheimer's disease is reflected in performance on odor identification: a structural MRI study

M Claire, FN Christine - Journal of the International …, 2003 - cambridge.org
The very high sensitivity and specificity of odor identification tasks in discriminating between
Alzheimer's patients and normals suggests that they reflect the presence of underlying …