A paradoxical role of reactive oxygen species in cancer signaling pathway: Physiology and pathology

V Ramalingam, R Rajaram - Process Biochemistry, 2021 - Elsevier
Reactive oxygen species (ROS) are generally recognized as major products in the cells that
are produced during oxygen utilization, cellular breakdown, and the incomplete degradation …

Role of reactive oxygen species in cancer progression: molecular mechanisms and recent advancements

V Aggarwal, HS Tuli, A Varol, F Thakral, MB Yerer… - Biomolecules, 2019 - mdpi.com
Reactive oxygen species (ROS) play a pivotal role in biological processes and continuous
ROS production in normal cells is controlled by the appropriate regulation between the silver …

[HTML][HTML] “Double-edged sword” effect of reactive oxygen species (ROS) in tumor development and carcinogenesis

Z Wenqi, P Zhuang, C Yixi, WU Yi, M Zhong… - Physiological …, 2023 - ncbi.nlm.nih.gov
Reactive oxygen species (ROS) are small reactive molecules produced by cellular
metabolism and regulate various physiological and pathological functions. Many studies …

Reactive oxygen species in cancer progression and its role in therapeutics

R Singh, PP Manna - Exploration of Medicine, 2022 - explorationpub.com
The redox status in pathogenesis is critically regulated by careful balance between the
generation of reactive oxygen species (ROS) and their elimination. Increased ROS level …

Reactive oxygen species: a key constituent in cancer survival

S Kumari, AK Badana, RR Malla - Biomarker insights, 2018 - journals.sagepub.com
Background: Cancer is one of the major heterogeneous disease with high morbidity and
mortality with poor prognosis. Elevated levels of reactive oxygen species (ROS), alteration in …

[HTML][HTML] Reactive oxygen species: role in the development of cancer and various chronic conditions

G Waris, H Ahsan - Journal of carcinogenesis, 2006 - ncbi.nlm.nih.gov
Oxygen derived species such as superoxide radical, hydrogen peroxide, singlet oxygen and
hydroxyl radical are well known to be cytotoxic and have been implicated in the etiology of a …

Reactive oxygen species in oncogenic transformation

L Behrend, G Henderson… - Biochemical society …, 2003 - portlandpress.com
Ever since ROS (reactive oxygen species) were shown to meet the criteria of true signalling
molecules, such as regulated production and a specific biological function, many efforts …

[HTML][HTML] Dual role of reactive oxygen species and their application in cancer therapy

R Huang, H Chen, J Liang, Y Li, J Yang, C Luo… - Journal of …, 2021 - ncbi.nlm.nih.gov
Reactive oxygen species (ROS) play a dual role in the initiation, development, suppression,
and treatment of cancer. Excess ROS can induce nuclear DNA, leading to cancer initiation …

The multifaceted role of reactive oxygen species in tumorigenesis

A Kirtonia, G Sethi, M Garg - Cellular and Molecular Life Sciences, 2020 - Springer
Redox homeostasis is an essential requirement of the biological systems for performing
various normal cellular functions including cellular growth, differentiation, senescence …

Reactive oxygen species: Role in carcinogenesis, cancer cell signaling and tumor progression

FL Sarmiento-Salinas, A Perez-Gonzalez… - Life Sciences, 2021 - Elsevier
Cancer is one of the major causes of death in the world and its global burden is expected to
continue increasing. In several types of cancers, reactive oxygen species (ROS) have been …