Four groups of rats were given amiodarone chronically at 25, 37ṁ5, 50, 75 mg kg− 1/12 h
for 3 weeks; on day 21 the animals were killed and blood, plasma, heart, lung, liver and fat …

Tissue distribution of amiodarone (Cordarone) and desethylamiodarone in the rat was
investigated after repeated oral application of various dosages of the drug. Serum and tissue …

The pharmacokinetics of amiodarone was studied after single and multiple dosing in two
groups of male Wistar and Albino rats. The first group (40 rats) received a single …

The pharmacokinetics and body distribution of amiodarone and desethylamiodarone were
studied in rats after single oral administration of 100 mg/kg and 200 mg/kg of amiodarone …

The pharmacokinetics of amiodarone was studied after single and multiple dosing in two
groups of male Wistar and Albino rats. the first group (40 rats) received a single …

Tissue distribution of amiodarone (Cordarone) and desethylamiodarone in the rat was
studied after repeated intraperitoneal administration of the drug. Tissue and serum …

The pharmacokinetics and body distribution of amiodarone and desethylamiodarone were
investigated in rats following a single intravenous dose of 100 mg/kg and 150 mg/kg of …

The tissue distribution and hepatic microsomal metabolism of amiodarone were studied in a
hyperlipidemic rat model. Rats were rendered hyperlipidemic by the intraperitoneal injection …

In order to better understand the pharmacokinetic differences between acute and chronic
regimens of the basic lipophilic antiarrhythmic, amiodarone (AM), a mass-balanced single …

This study was designed to determine serum and tissue concentra-tions of amiodarone and
its metabolite desethylamiodarone after chronic amiodarone administration in rabbits …