To the editor, Hepatic insulin resistance was correlated with diabetes and the progression of
NAFLD. In the latest article published by Shearer et al.,[1] the authors have demonstrated …

Abstract Protease-activated receptor 2 (PAR2) is a member of G protein-coupled receptors.
There are two types of PAR2 signaling pathways: Canonical G-protein signaling and β …

Excessive uptake of fatty acids and glucose by adipose tissue triggers adipocyte dysfunction
and infiltration of immune cells. Altered metabolic homeostasis in adipose tissue promotes …

Protease‐activated receptor 2 (PAR2) is a member of G‐protein‐coupled receptors and
affects ligand‐modulated calcium signaling. Although PAR2 signaling promotes obesity and …

Background Protease-activated protein-2 (PAR2) has been reported to regulate hepatic
insulin resistance condition in type 2 diabetes mice. However, the mechanism of lipid …

Objective Increases in hepatic and plasma cholesterol occur in patients with nonalcoholic
fatty liver disease (NAFLD), although the reason for this is not well understood. We …

Background & Aims PARP1 is a key mediator of cellular stress responses and critical in
multiple physiological and pathophysiological processes of cells. However, whether it is …

To the editor, We followed with interest the article by Ma et al [1] reporting that DRP1
deficiency led to mitochondrial dysfunction and increased mitochondrial DNA (mtDNA) …

To the editor, I read with interest the article entitled “Hepatocyte‐derived mannan‐binding
lectin serine protease 1 (MASP1)‐enriched small extracellular vesicles activate hepatic …

The potential role of proteinase activated receptor 2 (PAR2) in the development of age-
related obesity and insulin resistance is not well-understood. To address the hypothesis that …