The effect of analgesia on physiological systems has received little attention in trauma
research. Our aim was to examine the effect of two different analgesics, buprenorphine and …

Background It has been previously shown that anesthesia and analgesia can affect
outcomes in the rat burn model and that buprenorphine alleviated pain without drastically …

Excessive sympathetic outflow following trauma can lead to cardiac dysfunction,
inflammation, coagulopathy, and poor outcomes. We previously reported that buprenorphine …

Background and Objectives To investigate whether endogenous opioids might be involved
in the mechanisms that underlie hemorrhagic shock-induced analgesia, formalin tests were …

The endogenous opioid system has been reported to depress the cardiovascular system
during shock states, since naloxone, a potent opiate antagonist, enhances recovery of …

Background Nitric oxide (NO) plays multiple roles regulating the central nervous,
cardiovascular, and immune systems. Objective Our aim was to investigate the role of NO in …

We noted the effects of the mixed opiate agonist/antagonist nalbuphine on cardiovascular
function and survival in canine hemorrhagic shock. Anesthetized adult mongrel dogs were …

Methods: Adult male Sprague Dawley rats were randomly assigned to one of four groups
(n= 6): baseline (Thiobarb anesthesia), 5% isoflurane anesthesia, isoflurane-buprenorphine …

Endogenous opiates have been reported to have detrimental effects on the circulatory
system during hemorrhagic shock. However, the specific opiate receptor subtype which …

The endogenous opioids have been implicated as contributing factors to the cardiovascular
dysfunction of shock. Opiate receptor antagonists improve cardiovascular function and long …