Matrix metalloproteinases as biomarkers of atherosclerotic plaque instability

W Olejarz, D Łacheta… - International journal of …, 2020 - mdpi.com
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases
responsible for tissue remodeling and degradation of extracellular matrix (ECM) proteins …

Evidence for the involvement of matrix-degrading metalloproteinases (MMPs) in atherosclerosis

BA Brown, H Williams, SJ George - Progress in molecular biology and …, 2017 - Elsevier
Atherosclerosis leads to blockage of arteries, culminating in myocardial infarction, and
stroke. The involvement of matrix-degrading metalloproteinases (MMPs) in atherosclerosis …

Matrix metalloproteinases in coronary artery disease

B Mittal, A Mishra, A Srivastava, S Kumar… - Advances in clinical …, 2014 - Elsevier
Matrix metalloproteinases (MMP) are a family of zinc-containing endoproteinases that
degrade extracellular matrix (ECM) components. MMP have important roles in the …

Multidimensional contribution of matrix metalloproteinases to atherosclerotic plaque vulnerability: multiple mechanisms of inhibition to promote stability

JM Ruddy, JS Ikonomidis, JA Jones - Journal of vascular research, 2016 - karger.com
The prevalence of atherosclerotic disease continues to increase, and despite significant
reductions in major cardiovascular events with current medical interventions, an additional …

Matrix metalloproteinases and coronary artery diseases

U Ikeda, K Shimada - … Indexed and Peer‐Reviewed Journal for …, 2003 - Wiley Online Library
Matrix metalloproteinases (MMPs) play an important role in cardiovascular remodeling by
degrading the extracellular matrix. Enhanced MMP expression has been detected in the …

The role of matrix metalloproteinases in atherothrombosis

DFJ Ketelhuth, M Bäck - Current atherosclerosis reports, 2011 - Springer
The matrix metalloproteinase (MMP) family of enzymes is involved in arterial wall
extracellular matrix degradation and remodeling. The latter activities have been implicated …

Matrix metalloproteinases in cardiovascular disease

P Liu, M Sun, S Sader - Canadian Journal of Cardiology, 2006 - Elsevier
Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes that are regulated by
inflammatory signals to mediate changes in extracellular matrix. Members of the MMP family …

Matrix metalloproteinases: influence on smooth muscle cells and atherosclerotic plaque stability

JL Johnson - Expert review of cardiovascular therapy, 2007 - Taylor & Francis
Atherosclerotic plaque rupture, with subsequent occlusive thrombosis, is the underlying
cause of most cases of sudden cardiac death. Matrix metalloproteinases (MMPs) are thought …

The role of matrix metalloproteinase‐9 in atherosclerotic plaque instability

T Li, X Li, Y Feng, G Dong, Y Wang… - Mediators of …, 2020 - Wiley Online Library
Matrix metalloproteinase‐9 (MMP‐9) belongs to the MMP family and has been widely
investigated. Excessive MMP‐9 expression can enhance extracellular matrix degradation …

Effect of broad-spectrum matrix metalloproteinase inhibition on atherosclerotic plaque stability

JL Johnson, R Fritsche-Danielson… - Cardiovascular …, 2006 - academic.oup.com
Abstract Objective: Matrix metalloproteinases (MMPs) form a large family of enzymes that
collectively can degrade all components of the extracellular matrix, and there is widespread …