Oral administration is a highly attractive approach for the delivery of protein drugs. However,
oral protein therapeutics typically exhibit extremely poor bioavailability due to the harsh …

Trimethyl chitosan-cysteine conjugate (TMC-Cys) was synthesized in an attempt to combine
the mucoadhesion and the permeation enhancing effects of TMC and thiolated polymers …

Chitosan is an abundant natural cationic polysaccharide with excellent biodegradability,
bioadhesion, and biocompatibility. Chitosan is extensively researched for various particulate …

Oral administration of insulin faces multiple biological challenges, such as varied digestive
environments, mucin exclusion, and low epithelial cells' absorption. In the present study, a …

Self-assembled nanoparticles (NPs) from arginine-modified chitosan (CS-N-Arg) and
thiolated fucoidan (THL-fucoidan) were synthesized to enhance the transport of dextran and …

Diabetes mellitus is a highly prevalent metabolic and chronic disease affecting millions of
people in the world. The most common route of insulin therapy is the subcutaneous injection …

Despite advances in drug-delivery technologies, successful oral administration of protein
drugs remains an elusive challenge. When protein drugs are administered orally, they can …

The potential of nanoparticles (NPs) to overcome the barriers for oral delivery of protein
drugs have led to the development of platforms capable of improving their bioavailability …

Abstract Chitosan-alginate (CS/ALG) nanoparticles were prepared by formation of an
ionotropic pre-gelation of an alginate (ALG) core entrapping insulin, followed by chitosan …

Oral administration of protein drugs is greatly impeded by the lack of drug carriers that can
efficiently overcome the absorption barriers of mucosa tissue, which consists of not only …