Astrocytes play key roles in the regulation of brain energy metabolism, which has a major
impact on brain functions, including memory, neuroprotection, resistance to oxidative stress …

The brain has almost no energy reserve, but its activity coordinates organismal function, a
burden that requires precise coupling between neurotransmission and energy metabolism …

Brain energy metabolism has been the object of intense research in recent years.
Pioneering work has identified the different cell types involved in energy production and use …

As part of the blood-brain-barrier, astrocytes are ideally positioned between cerebral
vasculature and neuronal synapses to mediate nutrient uptake from the systemic circulation …

Dynamic adjustments to neuronal energy supply in response to synaptic activity are critical
for neuronal function. Glial cells known as astrocytes have processes that ensheath most …

Highlights•Astrocytes regulate brain energy supply at several loci.•Astrocytes adjust blood
flow at the capillary level via pericytes.•Controversy persists over lactate transfer between …

Classical neuroenergetics states that glucose is the exclusive energy substrate of brain cells
and its full oxidation provides all the necessary energy to support brain function. Recent data …

Neuronal activity is a high‐energy demanding process recruiting all neural cells that adapt
their metabolism to sustain the energy and redox balance of neurons. During …

Astrocytic energy demand is stimulated by K+ and glutamate uptake, signaling processes,
responses to neurotransmitters, Ca2+ fluxes, and filopodial motility. Astrocytes derive energy …

The causes of neurodegenerative disorders are multiple, and for most of them a mechanistic
understanding is still lacking. However, neurodegenerative diseases such as Alzheimer …