This chapter reviews the current knowledge of structure, function, regulation and study
methods of gap junctional intercellular communication (GJIC), as well as the role of GJIC …

Results from short-term tests for carcinogens and our advanced knowledge on cellular and
molecular mechanisms of carcinogenesis strongly suggest that carcinogens do not induce …

Gap Junctional intercellular communication (GJIC) mediates the direct transfer of low-
molecular weight factors from one cell to neighbouring ones. Since such factors include …

Gap junctional intercellular communication (GJIC) is considered to play a key role in the
maintenance of tissue independence and homeostasis in multicellular organisms by …

The loss of homeostasis which characterizes tumor growth is probably the result of a
deregulated intercellular communication capacity of the cancer cells. The deregulation of …

There is a growing body of evidence supporting the etiologic implication of gap junctional
intercellular communication disorders in carcinogenesis. Substantial progress has recently …

Gap junctional intercellular communication mediates the transfer of small molecules from the
cytoplasm of one cell to that of neighbouring cells. Connexins are the proteins that form the …

In spite of the early speculation by Loewenstein that one of the critical distinguishing
phenotypes of cancers from normal cells was the dysfunction of gap junctional intercellular …

If occupational tumors are excluded, cancer causes are largely unknown. Therefore, it
appeared useful to work out a theory explaining the complexity of this disease. More than …

Gap junctions, intercellular channels structured by the connexin protein family, have been
implicated in the control of cell homeostasis, proliferation, differentiation and death. A loss of …