Gap junctions are membrane structures made of intercellular channels which permit the
diffusion from cytoplasm to cytoplasm of small hydrophilic molecules. Nearly 40 years ago …

Gap junctional intercellular communication plays a key role in the maintenance of
homeostasis in multicellular organisms. Reflecting deranged homeostasis in cancer cells …

The development of the most efficacious strategy for the prevention and treatment of cancers
is based on understanding the underlying mechanisms of carcinogenesis. This includes the …

Publisher Summary This chapter focuses on the role of gap junctional intercellular
communication (GJIC) in cellular growth control and neoplasia and considers the large body …

Gap junctions, and their constituent connexin proteins, have long been considered to play a
role in the control of cell growth and carcinogenesis. The current review will attempt to …

Gap-junctional intercellular communication is thought to be essential for maintaining cellular
homeostasis and growth control. Its perturbation entails toxicological implications and it has …

To develop a strategy for efficacious intervention in order to prevent or treat various cancers,
one must understand the basic mechanism (s) by which various anticancer dietary factors …

Cancer was the first pathology to be associated with a dysfunction of gap junctions, over 40
years ago. Since then, data supporting this association have accumulated without …

Although the specific role of connexin-mediated gap junctional intercellular communication
in the control of cell homeostasis, proliferation, and death are still not clear, several lines of …

Evidence is accumulating that connexin (Cx) genes form a family of tumor-suppressor
genes. Our long-standing study revealed that, in almost all tumors, some abnormality in gap …