There is a large body of evidence suggesting the connexin gap junction proteins appear to
act as tumor suppressors, and their tumor inhibitory effect is usually attributed to their main …

We have developed a simple method to measure gapjunctional intercellular communication
(GJIC), by means of microinjection/dye transfer assay, in liver slices freshly removed from …

Modulation of gap junctional intercellular communication (GJIC) was studied in a multistep
model of human renal epithelial carcinogenesis. We report that the majority of primary …

Gap junction intercellular communication (GJIC) is involved in the regulation of many
cellular processes. The gap junction channels are made up of connexins and the flow of …

Introduction 3. Evolution and cancer 4. Theories of carcinogenesis: Overview 5. Stem cell
versus the de-differentiation theories 6. Initiation/promotion/progression theory of …

In this study, we investigated whether the tumor promoters, 12-O-tetradecanoylphorbol-13-
acetate (TPA), phenobarbital (PB), and 1, 1-bis (p-chlorophenyl)-2, 2, 2-trichloroethane …

During multistage liver carcinogenesis, there is a sequential decrease in gap junctional
intercellular communication (GJIC), associated with reduced expression of a major liver gap …

The paper by S. Ito and colleagues raises an important issue of increasing interest to
scientists working in chemical carcinogenesis. Since the early report by Trosko and …

Although several abnormalities in gap junction (GJ) structure and/or function have been
described in neoplasms, the molecular mechanisms responsible for many of the alterations …

A rat liver gap junction (GJ) cDNA probe that detects mRNA encoding the 32 Kd GJ‐protein
(connexin 32) was employed to study GJ‐protein gene expression in rat liver tumors …