Chronic obstructive pulmonary disease (COPD) is associated with features of accelerated
aging, including cellular senescence, DNA damage, oxidative stress, and extracellular …

Chronic obstructive pulmonary disease (COPD) is characterized by unrelenting airway
inflammation, loss of alveolar-capillary units, and a progressive decline in lung function …

Aging is one of the most important risk factors for most chronic diseases. The worldwide
increase in life expectancy has been accompanied by an increase in the prevalence of age …

Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death
worldwide, with increasing prevalence, in particular in the elderly. COPD is characterised by …

Chronic obstructive pulmonary disease (COPD) is recognized as a disease of accelerated
lung aging. Over the past two decades, mounting evidence suggests an accumulation of …

There is increasing evidence for a close relationship between aging and chronic
inflammatory diseases. COPD is a chronic inflammatory disease of the lungs, which …

Aging is a natural process characterized by progressive functional impairment and reduced
capacity to respond appropriately to environmental stimuli and injury. The incidence of two …

This paper reviews the potential participation of novel pathogenic mechanisms in chronic
obstructive pulmonary disease (COPD) relating to aging, including oxidative stress and …

COPD-derived fibroblasts have increased cellular senescence. Senescent cell accumulation
can induce tissue dysfunction by their senescence-associated secretory phenotype (SASP) …

Background: Alveolar cell senescence is accelerated in patients with chronic obstructive
pulmonary disease (COPD). Objectives: We tested the hypothesis that alveolar cell …