hydroxy-2-nonenal (HNE) is a reactive aldehyde produced by cells under conditions of
oxidative stress, which has been shown to react with proteins and …

Using the electron paramagnetic resonance (EPR) of spin-labeled stearic acid and a spin
label chemically attached to the membrane proteins, the interaction of miltefosine (MIL) and …

Although many terpenes have shown antitumor, antibacterial, antifungal, and antiparasitic
activity, the mechanism of action is not well established. Electron paramagnetic resonance …

Two β-carboline compounds, 8i and 6d, demonstrated in vitro antileishmanial activity
against Leishmania (L.) amazonensis promastigotes similar to that of miltefosine (MIL) …

Abstract Menadione (2-methyl-1, 4-naphtoquinone) is cytotoxic to hepatocytes. In order to
begin to investigate the changes in the physical state of membranes induced by this …

A novel chalcone derivative, LQFM064, demonstrated antileishmanial activity against
Leishmania (L.) amazonensis, with an IC 50 value of~ 10 μM for the promastigote form …

The sesquiterpene nerolidol is a membrane-active compound that has demonstrated
antitumor, antibacterial, antifungal and antiparasitic activities. In this study, we used electron …

Spin label electron paramagnetic resonance (EPR) spectroscopy was used to study the
mechanisms of action of ivermectin and curcumin against Leishmania (L.) amazonensis …

Promastigotes and amastigotes of Leishmania mexicana amazonensis, incubated in the
presence of 20 ng/ml of 12-O-tetradecanoyl phorbol-13-acetate (TPA), an exogenous …

In Plasmodium falciparum-parasitized erythrocytes, hemozoin (HZ) formation was
accompanied by enhanced formation of 4-hydroxynonenal (HNE)–protein adducts on the …