Objective To evaluate cytokine profile, vitamin D status, symptom score and quality of life in
patients with persistent allergic airway diseases sensitised to house dust mites (HDM) in …

Background Persistent allergic airway diseases cause a great burden worldwide. Their
pathogenesis is not clear enough. There is evidence that one of the recently described …

Background and Purpose. When house dust mite (HDM), a common allergen, comes into
the mucosal membrane, it may stimulate innate immunity. However, the precise role of …

Background Asthma is a chronic inflammatory disease of the airway that is characterized by
a Th2-type of immune response with increasing evidence for involvement of Th17 cells. The …

Background: Fungal aeroallergens might sensitize the airway which in turn produces a
specific cytokine profile. Objective: To evaluate the IL-25 and IL-33 profile in patients with …

Background Chronic rhinitis is a heterogeneous group of diseases that cause nasal
inflammation. And the nose may be a window into the lung in the concept of" one airway one …

Allergens are the main trigger that enhances airway type 2 inflammation, and the epithelium
is the first line of defense that reacts to its exposure. Therefore, epithelial‐derived mediators …

Background Preclinical studies implicate interleukin (IL)-1β as a key mediator of asthma and
have shown the efficacy of IL-1 antagonism for treatment of allergic airway inflammation; …

Background A variant in the IL-6 receptor (IL-6R) gene increases asthma risk and is
predicted to decrease IL-6 classic signaling and increase IL-6 trans-signaling. This suggests …

Introduction: Airway hyperresponsiveness (AHR) is a cardinal feature of asthma. Asthma is a
heterogenous disorder which consists of different phenotypes and endotypes. Mechanisms …