Neurodegenerative diseases such as Alzheimer's disease have proven resistant to new
treatments. The complexity of neurodegenerative disease mechanisms can be highlighted …

Progranulin (PGRN), a multifunctional growth factor expressed in various tissues, is involved
in a diversity of physiologic and pathological processes, including cell proliferation, wound …

Progranulin (PGRN, encoded by the GRN gene) plays a key role in the development,
survival, function, and maintenance of neurons and microglia in the mammalian brain. It …

Progranulin (PGRN), encoded by the GRN gene in humans, is a secreted growth factor
implicated in a multitude of processes ranging from regulation of inflammation to wound …

Progranulin (PGRN) has recently emerged as a key player in a subset of frontotemporal
dementias (FTD). Numerous mutations in the progranulin gene have been identified in …

Long‐term or severe lack of protective factors is important in the pathogenesis of
neurodegenerative dementia. Progranulin (PGRN), a neurotrophic factor expressed mainly …

Progranulin (PGRN) is a multifunctional protein that has attracted significant attention in the
neuroscience community following the recent discovery of PGRN mutations in some cases …

Background The essential role of progranulin (PGRN) as a neurotrophic factor has been
demonstrated by the discovery that haploinsufficiency due to GRN gene mutations causes …

Progranulin (PGRN) is a pleiotropic protein that has gained the attention of the neuroscience
community with recent discoveries of mutations in the gene for PGRN that cause …

It is well known that progranulin protein is involved in wound repair, inflammation, and tumor
formation. The wedding between progranulin and brain was celebrated in 2006 with the …