Effect of quercetin and its glucuronide metabolite upon 6-hydorxydopamine-induced oxidative damage in Neuro-2a cells
R Mukai, K Kawabata, S Otsuka, A Ishisaka… - Free radical …, 2012 - Taylor & Francis
Quercetin is ubiquitously distributed in plant foods. This antioxidative polyphenol is mostly
converted to conjugated metabolites in the body. Parkinson disease (PD) has been …
converted to conjugated metabolites in the body. Parkinson disease (PD) has been …
Effect of a conjugated quercetin metabolite, quercetin 3-glucuronide, on lipid hydroperoxide-dependent formation of reactive oxygen species in differentiated PC-12 …
M Shirai, Y Kawai, R Yamanishi, T Kinoshita… - Free Radical …, 2006 - Taylor & Francis
To assess the efficacy of conjugated quercetin metabolites as attenuators for oxidative stress
in the central nervous system, we measured the 13-hydroperoxyoctadecadienoic acid (13 …
in the central nervous system, we measured the 13-hydroperoxyoctadecadienoic acid (13 …
Lack of robust protective effect of quercetin in two types of 6-hydroxydopamine-induced parkinsonian models in rats and dopaminergic cell cultures
TM Kääriäinen, M Piltonen, B Ossola, H Kekki… - Brain research, 2008 - Elsevier
In the present study, we examined the ability of a flavonoid quercetin to prevent 6-
hydroxydopamine (6-OHDA)-induced oxygen radical formation and cytotoxicity in vitro and …
hydroxydopamine (6-OHDA)-induced oxygen radical formation and cytotoxicity in vitro and …
Protective effects of quercetin glycosides, rutin, and isoquercetrin against 6-hydroxydopamine (6-OHDA)-induced neurotoxicity in rat pheochromocytoma (PC-12) cells
KB Magalingam, A Radhakrishnan… - International journal …, 2016 - journals.sagepub.com
There is increasing evidence that free radicals induced oxidative stress is a major causative
agent in the pathogenesis of neurodegenerative diseases, particularly Parkinson's disease …
agent in the pathogenesis of neurodegenerative diseases, particularly Parkinson's disease …
Effects of quercetin and quercetin-3-O-glycosides on oxidative damage in rat C6 glioma cells
M Zielińska, M Gülden, H Seibert - Environmental Toxicology and …, 2003 - Elsevier
Flavonoids are reported to be powerful antioxidants in cell free systems. They naturally
occur as glycosides rather than as aglycon. In this study the ability of the flavonoid quercetin …
occur as glycosides rather than as aglycon. In this study the ability of the flavonoid quercetin …
Neuroprotective effect of bioflavonoid quercetin in 6-hydroxydopamine-induced oxidative stress biomarkers in the rat striatum
N Haleagrahara, CJ Siew, NK Mitra, M Kumari - Neuroscience letters, 2011 - Elsevier
An increasing large body of research on Parkinson's disease (PD) has focused on the
understanding of the mechanisms behind the potential neuro protection offered by …
understanding of the mechanisms behind the potential neuro protection offered by …
Identification of quercetin 3-O-β-D-glucuronide as an antioxidative metabolite in rat plasma after oral administration of quercetin
JH Moon, T Tsushida, K Nakahara, J Terao - Free Radical Biology and …, 2001 - Elsevier
The potential beneficial effect of dietary quercetin (3, 3′, 4′, 5, 7-pentahydroxyflavone)
has attracted much attention in relation to the prevention of cardiovascular disease. It is …
has attracted much attention in relation to the prevention of cardiovascular disease. It is …
Quercetin-3-O-β-d-glucopyranoside, a dietary flavonoid, protects PC12 cells from H2O2-induced cytotoxicity through inhibition of reactive oxygen species
Y Shokoohinia, M Rashidi, L Hosseinzadeh… - Food chemistry, 2015 - Elsevier
Since flavonols are antioxidant agents, they could in principle, beneficially affect
neurodegenerative diseases where reactive oxygen species are involved. Quercetin …
neurodegenerative diseases where reactive oxygen species are involved. Quercetin …
Neuroprotective properties of the natural phenolic antioxidants curcumin and naringenin but not quercetin and fisetin in a 6-OHDA model of Parkinson's disease
V Zbarsky, KP Datla, S Parkar, DK Rai… - Free radical …, 2005 - Taylor & Francis
Although the cause of dopaminergic cell death in Parkinson's disease (PD) remains
unknown, oxidative stress has been strongly implicated. Because of their ability to combat …
unknown, oxidative stress has been strongly implicated. Because of their ability to combat …
Quercetin glycosides induced neuroprotection by changes in the gene expression in a cellular model of Parkinson's disease
KB Magalingam, A Radhakrishnan, P Ramdas… - Journal of Molecular …, 2015 - Springer
Quercetin glycosides, rutin and isoquercitrin, are potent antioxidants that have been found to
possess neuroprotective effect in diseases like Parkinson's and Alzheimer's disease. In the …
possess neuroprotective effect in diseases like Parkinson's and Alzheimer's disease. In the …