Many modern therapeutic approaches are based on precise diagnostic evidence, where
imaging procedures play an essential role. To date, in the diagnostic field, a plethora of …

The discovery and development of a biologically active molecule with therapeutic properties
is an increasingly complex task, highly unpredictable at the early stages and frequently …

In this monograph the contribution of imaging modalities to the various stages of drug
discovery and development, from early target validation to their use in clinical development …

This chapter describes the process of bringing radiopharmaceuticals from preclinical
investigations to first-in-man studies, specifically the first application of a new …

The pharmaceutical research community has had a longstanding guideline that for
experimental therapeutic preclinical studies at least six animals are required for each data …

The fields of molecular biology, immunology and genetics have generated many important
developments that advance the understanding of the induction and progression of …

There is increasing evidence that human medical imaging can help answer key questions
that arise during the drug development process. Imaging modalities such as magnetic …

Emerging imaging technologies are finding wide application in drug development. Their
potential to facilitate business and regulatory decision making increases with validation …

Drug discovery and development is a time-consuming and costly process, which may take
approximately 15 years to advance from laboratory discovery to FDA approval and require …

Molecular imaging arose as a novel discipline in the mid-1990s to study molecular and
cellular events in a non-minimally or minimally invasive manner in living subjects. It rapidly …