Sex reversal syndrome is a kind of human genetic disease about gender dysplasia, which is
characterised by inconsistency between gonadal sexuality and chromosome sexuality; the …

Purpose To investigate the clinical characteristics of different categories of sex-reversed 46,
XX individuals and their relationships with chromosomal karyotype and the SRY gene …

Summary 46, XX male sex reversal syndrome is one of the rarest sex chromosomal
aberrations. The presence of SRY gene on one of the X chromosomes is the most frequent …

In humans, sexual differentiation is directed by SRY, a master regulatory gene located at the
Y chromosome. This gene initiates the male pathway or represses the female pathway by …

The main factor influencing the sex determination of an embryo is the genetic sex
determined by the presence or absence of the Y chromosome. However, some individuals …

BACKGROUND: The importance of the Y chromosome in male determination hasbeen well
established for a long time. The presence of a translocation of chromosomal material …

Background To review the possible mechanisms proposed to explain the etiology of 46, XX
sex reversal by investigating the clinical characteristics and their relationships with …

PURPOSE: The XX male syndrome presents with a spectrum of clinical appearances from
phenotypic male individuals to true hermaphrodites. Previous reports established the sex …

The sex-determining region on the Y chromosome (SRY) gene guides male sexual
development. However, individuals with sex reversal syndrome (46, XX males and 46, XX …

Prenatal diagnosis of disorder of sex development (DSD) is very rare and is estimated to
occur in 1/2500 pregnancies. A group of DSDs are the 46, XX testicular DSD. Today, the …