Among the popular animal models of Parkinson's disease (PD) commonly used in research
are those that employ neurotoxins, especially 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine …

Animal models are a very important approach to study the pathogenesis and therapeutic
intervention strategies of human diseases. Since many human disorders do not arise …

Among the most widely used models of Parkinson's disease (PD) are those that employ
toxins, especially 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP). Depending on the …

The characteristic brain pathology and motor and nonmotor symptoms of Parkinson's
disease (PD) are well established. However, the details regarding the causes of the disease …

Conclusion The discovery that a rather simple chemical substance can produce such a
highly selective neuronal degeneration in the substantia nigra, the brain area most affected …

Environmental toxins are harmful substances detrimental to humans. Constant exposure to
these fatal neurotoxins can cause various neurodegenerative disorders. Although …

Parkinson's disease (PD) is characterized by a progressive degeneration of dopamine (DA)
neurons and gradual worsening of motor symptoms. The investigation of progressive …

Methy-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) is a potent neurotoxin extensively used
to model Parkinson's disease (PD). A cascade of deleterous events, in which mitochondria …

The biochemical and cellular changes that occur following administration of 1-methyl-4-
phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) are remarkably similar to that seen in idiopathic …

Parkinson's disease is one of the major neurodegenerative disorders. This disease is mainly
characterized by tremor, bradykinesia, rigidity and postural instability that results primarily …