Non-human primate (NHP) models of Parkinson's disease (PD) have been essential in
understanding the pathophysiology and neural mechanisms underlying PD. The most …

Although a valuable 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) animal model of
human Parkinson's disease has been developed, our knowledge of the course of nigral …

In human and subhuman primates, 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)
produces irreversible clinical, biochemical and neuropathological alterations highly …

Evidence discussed in this review article lends strong support in favor of an etiologic role of
environmental factors in Parkinson's disease. First, thanks to the discovery of MPTP (1 …

Parkinson's disease (PD) is the second most common neurodegenerative disease after
Alzheimer's disease, affecting about seven to 10 million patients worldwide. The major …

We evaluated neurochemically, behaviorally, and neuropathologically the availability of 1-
methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-treated C57 black (BL) mice as a …

Parkinson's disease (PD) is the second most frequent neurodegenerative disorder after
Alzheimer's disease. The main clinical features of PD include tremor, bradykinesia, rigidity …

Mechanisms responsible for 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced
dopamine (DA) neuronal death remain unknown and in mice it is even unclear whether …

Parkinson's disease (PD) is a profound movement disorder resulting from progressive
degeneration of the nigrostriatal dopaminergic pathway. Although its etiology remains …

MPTP-induced neurotoxicity is one of the experimental models most commonly used to
study the pathogenesis of Parkinson's disease (PD). MPTP administered in vivo to mice …