Preclinical models of nontuberculous mycobacteria infection for early drug discovery and vaccine research

E Rampacci, V Stefanetti, F Passamonti… - Pathogens, 2020 - mdpi.com
Nontuberculous mycobacteria (NTM) represent an increasingly prevalent etiology of soft
tissue infections in animals and humans. NTM are widely distributed in the environment and …

The complexities and challenges of preventing and treating nontuberculous mycobacterial diseases

SL Baldwin, SE Larsen, D Ordway… - PLoS neglected …, 2019 - journals.plos.org
Seemingly innocuous nontuberculous mycobacteria (NTM) species, classified by their slow
or rapid growth rates, can cause a wide range of illnesses, from skin ulceration to severe …

Non-tuberculous mycobacterial disease: progress and advances in the development of novel candidate and repurposed drugs

Y Gu, W Nie, H Huang, X Yu - Frontiers in Cellular and Infection …, 2023 - frontiersin.org
Non-tuberculous mycobacteria (NTM) are opportunistic pathogens that can infect all body
tissues and organs. In particular, the lungs are the most commonly involved organ, with NTM …

In vitro drug discovery models for Mycobacterium tuberculosis relevant for host infection

T Parish - Expert Opinion on Drug Discovery, 2020 - Taylor & Francis
Introduction: Tuberculosis is the leading cause of death from infectious disease. Current
drug therapy requires a combination of antibiotics taken over> 6 months. An urgent need for …

Drug testing in mouse models of tuberculosis and nontuberculous mycobacterial infections

BV Nikonenko, AS Apt - Tuberculosis, 2013 - Elsevier
Mice as a species are susceptible to tuberculosis infection while mouse inbred strains
present wide spectrum of susceptibility/resistance to this infection. However, non …

An ex vivo culture model for screening drug activity against in vivo phenotypes of Mycobacterium tuberculosis

DJ Turner, SL Hoyle, VA Snewin, MP Gares… - …, 2002 - microbiologyresearch.org
Since the activity of drugs against Mycobacterium tuberculosis grown in microbiological
culture can differ from their activity against bacteria present in infected tissues, compounds …

State-of-the-art treatment strategies for nontuberculous mycobacteria infections

MC Muñoz-Egea, N Carrasco-Antón… - Expert Opinion on …, 2020 - Taylor & Francis
ABSTRACT Introduction Non-tuberculous Mycobacteria (NTM) are a group of organisms
whose importance in medicine seems to be increasing in recent times. The increasing …

Antimycobacterial strategies to evade antimicrobial resistance in the nontuberculous mycobacteria

BC Millar, JE Moore - The International Journal of …, 2019 - journals.lww.com
The nontuberculous mycobacteria (NTM) have recently emerged as important bacterial
pathogens of both animals and humans. Of particular, concern is the high level of …

Resistance mechanisms and drug susceptibility testing of nontuberculous mycobacteria

J van Ingen, MJ Boeree, D van Soolingen… - Drug Resistance …, 2012 - Elsevier
Nontuberculous mycobacteria (NTM) are increasingly recognized as causative agents of
opportunistic infections in humans. For most NTM infections the therapy of choice is drug …

Discovery of Common Putative Drug Targets and Vaccine Candidates for Mycobacterium tuberculosis sp.

RM Nalamolu, C Pasala, SK Katari… - Journal of Drug Delivery …, 2019 - jddtonline.info
Mycobacterium tuberculosis is the bacteria that cause tuberculosis (TB), an infection that
usually affects the lungs and can be fatal without proper treatment. Combating through …