Sirtuins are the class III of histone deacetylases whose deacetylate of histones is dependent
on nicotinamide adenine dinucleotide (NAD+). Among seven sirtuins, SIRT1 plays a critical …

Sirtuins are NAD+ dependent histone deacetylases (HDAC) that play a pivotal role in
neuroprotection and cellular senescence. SIRT1-7 are different homologs from sirtuins. They …

SIRT1 is the mammalian homologue of yeast silent information regulator (Sir)-2, a member
of the sirtuin family of protein deacetylases which have gained much attention as mediators …

Abstract Sirtuin 2 (SIRT2) is an NAD+-dependent deacetylase that was under studied
compared to other sirtuin family members. SIRT2 is the only sirtuin protein which is …

Sirtuin 1 (SIRT1), the mammalian Sir2 homologue, is a class III histone deacetylase shown
to act on a wide range of histones and non-histone substrates. Numerous studies have …

As a type of nicotinamide adenine dinucleotide (NAD+)-dependent deacetylases, sirtuin 2
(SIRT2) is predominantly found in the cytoplasm of cells in the central nervous system …

Abstract Background Sirtuins (SIRTs) are NAD+ dependent lysine deacetylases which are
conserved from bacteria to humans and have been associated with longevity and lifespan …

Sirtuins are NAD‐dependent protein deacetylases known to have protective effects against
age‐related diseases such as cancer, diabetes, cardiovascular and neurodegenerative …

Parkinson's disease (PD), the main risk factor of which is age, is one of the most common
neurodegenerative diseases, thus presenting a substantial burden on the health of affected …

Abstract Sirtuin1 (SIRT1) has protective effects in some neurodegenerative disease models,
but it is not clear whether SIRT1 play the same role on inflammation-mediated Parkinson's …