Maternal aging has been reported to reduce oocyte quality and, in turn, lower the
developmental potential of the resulting embryos. Here, we show that maternally aged …

STUDY QUESTION Does in vivo aging of mouse oocytes affect mitochondrial function?
SUMMARY ANSWER Mitochondrial function was impaired in post-ovulatory in vivo-aged …

Purpose To establish the phenotype of reproductive aging in our mouse model. To test the
hypotheses that reproductive aging is associated with a decrease in mitochondrial …

Advanced maternal age is an emerging health problem which involves many functional and
structural alterations in oocytes, and its study is relevant to design better approaches to …

Oocytes from aging ovaries contain mitochondria with morphological and genetic flaws. How
these flaws relate to phenotypes of oocyte developmental compromise associated with …

The hamster is a useful model of human reproductive biology because its oocytes are
similar to those in humans in terms of size and structural stability. In the present study we …

The objective of this work was to determine the role of mitochondria in the loss of oocyte
quality with maternal aging. Our results show that mitochondrial DNA (mtDNA) copy number …

Pre-maturation aging of immature oocytes may adversely affect the fate of an oocyte.
Oxidative stress is one of the most detrimental factors affecting oocyte developmental …

It is well established that age-related decline of a woman's fertility is related to the poor
developmental potential of her gametes. The age-associated decline in female fertility is …

BACKGROUND: The senescence-accelerated mouse (SAM) has been shown to exhibit
ageing-associated mitochondrial dysfunction and oxidative stress, and early decline in …