The omnipresent ubiquitin–proteasome system (UPS) is an ATP-dependent enzymatic
machinery that targets substrate proteins for degradation by the 26S proteasome by tagging …

Ubiquitination is a stable, reversible posttranslational modification of target proteins by
covalent ligation of the small chaperone protein ubiquitin. Most commonly ubiquitination …

We purified by fractionation on 10-40% glycerol gradients, 26S proteasomes from normal
human spermatozoa. These proteasomes, which participate in the ATP-dependent …

The 26S proteasome is a multi-subunit protease specifically targeting ubiquitinated proteins.
A consensus has emerged from studies by multiple laboratories on the role of sperm-borne …

In this work, we have investigated the role of the sperm proteasome during in vitro
fertilization (IVF) and gamete interaction in the mouse. Proteasome activity was measured in …

The proteasome, a multienzymatic protease complex is present in human sperm. Here we
present evidence indicating that the proteasome has an extracellular localization, on the …

The proteasome is a multicatalytic cellular complex, which possess three different enzymatic
activities, trypsin‐like, chymotrypsin‐like, and peptidylglutamyl peptidase. Its function is to …

Despite years of research work, biologists remain divided over the issue of zona pellucida
function during fertilization and the mode of sperm-ZP penetration. The present review …

BACKGROUND: Fertilization in mammals comprises the sequential interactions of the sperm
with the cumulus oophorus, zona pellucida, and oocyte plasma membrane. Here we …

The 26S proteasome, which is a multi-subunit protease with specificity for substrate proteins
that are postranslationally modified by ubiquitination, has been implicated in acrosomal …