During gene transcription, the RNA polymerase (Pol) active center can catalyze RNA
cleavage. This intrinsic cleavage activity is strong for Pol I and Pol III but very weak for Pol II …

The carboxy-terminal domain (CTD) of RNA polymerase (Pol) II is an intrinsically disordered
low-complexity region that is critical for pre-mRNA transcription and processing. The CTD …

The largest subunit of RNA polymerase (Pol) II harbors an evolutionarily conserved C‐
terminal domain (CTD), composed of heptapeptide repeats, central to the transcriptional …

Eukaryotic gene regulation and pre-mRNA transcription depend on the carboxy-terminal
domain (CTD) of RNA polymerase (Pol) II. Due to its highly repetitive, intrinsically disordered …

The human Mediator complex interacts extensively with the RNA polymerase II (Pol II)
enzyme and recent data from our lab suggest activator-induced structural shifts within …

Eukaryotic RNA polymerase II (Pol II) has evolved an array of heptad repeats with the
consensus sequence Tyr1‐Ser2‐Pro3‐Thr4‐Ser5‐Pro6‐Ser7 at the carboxy‐terminal …

The RNA polymerase II (Pol II) C-terminal domain (CTD) serves as a docking site for
numerous proteins, bridging various nuclear processes to transcription. The recruitment of …

The C‐terminal domain (CTD) of the largest subunit (RPB1) of eukaryotic RNA polymerase II
is essential for pol II function and has been shown to play a number of important roles in the …

Differently phosphorylated forms of RNA polymerase (Pol) II are required to guide the
enzyme through the transcription cycle. Here, we show that a phosphorylation …

Background The largest sub-unit of RNA polymerase II, Rpb1p, has long been known to be
subject to post-translational modifications that influence various aspects of pre-mRNA …