Tumor-induced remodeling of the microenvironment in lymph nodes (LNs) includes the
formation of blood vessels, which goes beyond the regulation of metabolism, and shaping a …

Tumor-induced remodeling of the microenvironment relies on the formation of blood vessels,
which go beyond the regulation of metabolism, shaping a maladapted survival niche for …

Blood endothelial cells display remarkable plasticity depending on the demands of a
malignant microenvironment. While studies in solid tumors focus on their role in metabolic …

The lymphatic vasculature has been widely described and explored for its key functions in
fluid homeostasis and in the organization and modulation of the immune response. Besides …

Lymphatic vessels in the tumor microenvironment are known to foster tumor metastasis in
many cancers, and they can undergo activation, hyperplasia, and lymphangiogenesis in the …

Highlights•Tumor lymphangiogenesis is associated with a poor prognosis in many cancer
types.•Lymphatic vessels provide a dissemination route for tumor cells.•Lymphatic vessels …

The lymphatic system is implicated in interstitial fluid balance regulation, immune cell
trafficking, oedema and cancer metastasis. However, the sequence of events that initiate …

Lymphatic remodeling in tumor microenvironments correlates with progression and
metastasis, and local lymphatic vessels play complex and poorly understood roles in tumor …

High endothelial venules (HEVs) are structurally distinct blood vessels that develop during
embryonic and neonatal life in all secondary lymphoid organs except the spleen. HEVs are …

Research over the last decades has provided strong evidence for the pivotal role of the
tumor-associated blood and lymphatic vasculature in supporting immunoevasion and in …