Melatonin (N-acetyl-5-methoxytryptamine, MEL), its kynurenic (N 1-acetyl-N 2-formyl-5-
methoxykynurenine, AFMK) and indolic derivatives (6-hydroxymelatonin, 6 (OH) MEL and 5 …

Melanogenesis is a key parameter of differentiation in melanocytes and melanoma cells;
therefore, search for factors regulating this pathway are strongly desired. Herein, we …

Among skin cancers, melanoma has the highest mortality rate. The heterogeneous genetic
melanoma background leads to a tumor-propagating capacity particularly important in …

Melanoma is a leading cause of cancer deaths worldwide. Although immunotherapy has
revolutionized the treatment for some patients, resistance towards therapy and unwanted …

Melatonin is present in all living organisms where it displays a diversity of physiological
functions. Attenuation of melanogenesis by melatonin has been reported in some mammals …

Melanoma is the most aggressive type of skin cancer, with a greater risk of metastasis and a
higher prevalence and mortality rate. This cancer type has been demonstrated to develop …

Melatonin, a derivative of tryptophan that is present in all vertebrates, was first described in
bovine pineal gland. It is known that melatonin is a highly conserved molecule, present also …

Melatonin is an indoleamine synthesized in the pineal gland, and after its release into the
blood, it has an extensive repertoire of biological activities, including antitumoral properties …

Melatonin influences mammalian coat colour and hair follicle pigmentation and also weakly
alters the electrical stimulation of retinal cells in the eyes. A direct melanocytic response to …

Background: Melatonin, the principal hormone produced by the pineal gland, manifests
strong potency of inhibiting growth of dermal melanoma cells both under in vitro and in vivo …