Molecular insight into the study of adult T-cell leukemia/lymphoma (ATLL): Ten-year studies on HTLV-1 associated diseases in an endemic region

F Ashrafi, M Rahimzada, M Parandi, A Mirhosseini… - Gene, 2022 - Elsevier
The outcome of successful infection, including human T-cell leukemia virus type 1 (HTLV-1),
is determined by the interactions between the host and the infectious agent. Ten years of …

Human T-Cell Leukemia Virus Type 1 Oncogenesis between Active Expression and Latency: A Possible Source for the Development of Therapeutic Targets

F Marino-Merlo, S Grelli, A Mastino, M Lai… - International Journal of …, 2023 - mdpi.com
The human T-cell leukemia virus type 1 (HTLV-1) is the only known human oncogenic
retrovirus. HTLV-1 can cause a type of cancer called adult T-cell leukemia/lymphoma (ATL) …

Pathogenicity and virulence of human T lymphotropic virus type-1 (HTLV-1) in oncogenesis: adult T-cell leukemia/lymphoma (ATLL)

S Ahmadi Ghezeldasht, DJ Blackbourn… - Critical Reviews in …, 2023 - Taylor & Francis
Adult T-cell leukemia/lymphoma (ATLL) is an aggressive malignancy of CD4+ T
lymphocytes caused by human T lymphotropic virus type-1 (HTLV-1) infection. HTLV-1 was …

Signaling factors potentially associated to the pathogenesis of adult T-cell leukemia/lymphoma: a network-analysis and novel findings assessment

SH Mozhgani, MZ Ghobadi, M Norouzi, H Rahimi… - Virus research, 2022 - Elsevier
Adult T-cell leukemia/lymphoma (ATLL) is a human T-cell leukemia virus (HTLV) type 1-
associated disease of TCD4+ cell transformation. Despite extensive studies on ATLL …

Assessment of HTLV-1 proviral load, LAT, BIM, c-FOS and RAD51 gene expression in adult T cell leukemia/lymphoma

S Ramezani, A Shirdel, H Rafatpanah… - Medical microbiology …, 2017 - Springer
Adult T cell leukemia/lymphoma (ATLL) is a life-threatening malignancy of HTLV-1 infected
Th lymphocytes. In the present study host–virus interactions were investigated by …

HTLV-1-host interactions on the development of adult T cell leukemia/lymphoma: virus and host gene expressions

H Tarokhian, H Rahimi, A Mosavat, A Shirdel… - BMC cancer, 2018 - Springer
Background Adult T-cell leukemia/lymphoma (ATLL) is a lymphoproliferative disorder of
HTLV-1-host interactions in infected TCD4+ cells. In this study, the HTLV-1 proviral load …

[HTML][HTML] Evaluation of the role of TAX, HBZ, and HTLV-1 proviral load on the survival of ATLL patients

MM Akbarin, A Shirdel, A Bari, ST Mohaddes… - Blood …, 2017 - ncbi.nlm.nih.gov
Background Adult T-cell leukemia/lymphoma (ATLL) is an aggressive malignancy with very
poor prognosis and short survival, caused by the human T-lymphotropic virus type-1 (HTLV …

HTLV-1 infection promotes excessive T cell activation and transformation into adult T cell leukemia/lymphoma

BJY Tan, K Sugata, O Reda, M Matsuo… - The Journal of …, 2021 - Am Soc Clin Investig
Human T cell leukemia virus type 1 (HTLV-1) mainly infects CD4+ T cells and induces
chronic, persistent infection in infected individuals, with some developing adult T cell …

HBZ and its roles in HTLV-1 oncogenesis

T Zhao, M Matsuoka - Frontiers in microbiology, 2012 - frontiersin.org
Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia (ATL). The minus
strand of HTLV-1 provirus encodes a bZIP protein donated as HTLV-1 bZIP factor (HBZ) …

Clinical applications of genomic alterations in ATLL: predictive markers and therapeutic targets

N Yoshida, H Miyoshi, K Ohshima - Cancers, 2021 - mdpi.com
Simple Summary In this review paper, we aim to summarize recent findings of genomic
alterations found in adult T-cell leukemia/lymphoma (ATLL), which is an incurable disease …