To investigate the relevance of zinc in host-pathogen interactions, we have constructed
Salmonella enterica mutant strains in which the znuA gene, which encodes the periplasmic …

The pathways ensuring the efficient uptake of zinc are crucial for the ability of bacteria to
multiply in the infected host. To better understand bacterial responses to zinc deficiency, we …

ABSTRACT The Salmonella enterica serovar Typhimurium znuABC genes encoding a high-
affinity zinc uptake system and its regulatory zur gene have been cloned. Salmonella …

Due to its favorable chemical properties, zinc is used as a structural or catalytic cofactor in a
very large number of proteins. Despite the apparent abundance of this metal in all cell types …

Background Zinc is an essential element for all living cells. Recent studies have shown that
the ZnuABC zinc uptake system significantly contributes to the ability of several pathogens to …

Zinc is an essential metal for cellular homeostasis and function in both eukaryotes and
prokaryotes. To acquire this essential nutrient, bacteria employ transporters characterized by …

Abstract Background In Gram-negative bacteria the ZnuABC transporter ensures adequate
zinc import in Zn (II)-poor environments, like those encountered by pathogens within the …

Roles of the ZnuACB and ZupT transporters were assessed in Escherichia coli K-12 and
uropathogenic E. coli (UPEC) CFT073. K-12 and CFT073 Δ znu Δ zupT mutants …

Zinc is an essential cofactor required for life and, as such, mechanisms exist for its
homeostatic maintenance in biological systems. Despite the evolutionary distance between …

Zinc ions play indispensable roles in biological chemistry. However, bacteria have an
impressive ability to acquire Zn 2+ from the environment, making it exceptionally difficult to …