[HTML][HTML] Direct-acting antiviral treatment downregulates immune checkpoint inhibitor expression in patients with chronic hepatitis C
Chronic hepatitis C (CHC) infection is associated with increased TIM-3, PD-1 immune
checkpoint receptors expression that inhibits adaptive T cells and increases NK cell …
checkpoint receptors expression that inhibits adaptive T cells and increases NK cell …
Differential expression of immune inhibitory checkpoint signatures on antiviral and inflammatory T cell populations in chronic hepatitis B
H Cooksley, A Riva, K Katzarov… - Journal of Interferon & …, 2018 - liebertpub.com
Virus-specific T cells are critical in mediating the pathogenesis of hepatitis B virus (HBV)
infection. Interferon gamma (IFNγ)-producing T cells are associated with resolution; in …
infection. Interferon gamma (IFNγ)-producing T cells are associated with resolution; in …
[HTML][HTML] Activation and transcriptional profile of monocytes and CD8+ T cells are altered in checkpoint inhibitor-related hepatitis
Background & Aims Checkpoint inhibitor-related hepatitis (CPI-Hep) is an emerging clinical
challenge. We aimed to gain insights into the immunopathology of CPI-Hep by …
challenge. We aimed to gain insights into the immunopathology of CPI-Hep by …
Expressions of inhibitory checkpoint molecules in acute and chronic HBV and HCV infections: Implications for therapeutic monitoring and personalized therapy
MS Hakim, N Rahmadika… - Reviews in Medical …, 2020 - Wiley Online Library
The function of T cells is tightly controlled by positive and negative regulations to ensure
both successful pathogen elimination and limitation of immune‐mediated pathology. One of …
both successful pathogen elimination and limitation of immune‐mediated pathology. One of …
[HTML][HTML] Partial restoration of immune response in Hepatitis C patients after viral clearance by direct-acting antiviral therapy
M Llorens-Revull, MI Costafreda, A Rico… - Plos one, 2021 - journals.plos.org
Background & aims HCV CD4+ and CD8+ specific T cells responses are functionally
impaired during chronic hepatitis C infection. DAAs therapies eradicate HCV infection in …
impaired during chronic hepatitis C infection. DAAs therapies eradicate HCV infection in …
[HTML][HTML] Increased intrahepatic expression of immune checkpoint molecules in autoimmune liver disease
Z Macek Jilkova, MN Hilleret, T Gerster, N Sturm… - Cells, 2021 - mdpi.com
Immune checkpoint molecules (ICM) are critical in maintaining immunologic homeostasis
and participate in preventing or promoting autoimmune disease development. Exploring a …
and participate in preventing or promoting autoimmune disease development. Exploring a …
[HTML][HTML] Therapeutic inhibition of monocyte recruitment prevents checkpoint inhibitor-induced hepatitis
CLC Gudd, E Mitchell, SR Atkinson… - … for Immunotherapy of …, 2024 - ncbi.nlm.nih.gov
Background Checkpoint inhibitor-induced hepatitis (CPI-hepatitis) is an emerging problem
with the widening use of CPIs in cancer immunotherapy. Here, we developed a mouse …
with the widening use of CPIs in cancer immunotherapy. Here, we developed a mouse …
[HTML][HTML] Regulatory phenotype, PD-1 and TLR3 expression in T cells and monocytes from HCV patients undergoing antiviral therapy: a randomized clinical trial
S Su, H He, L Kong, Y Zhang, S Zhao, R Wang… - PLoS …, 2014 - journals.plos.org
Background & Aims The cellular immunity has a profound impact on the status of hepatitis C
virus (HCV) infection. However, the response of cellular immunity on the virological …
virus (HCV) infection. However, the response of cellular immunity on the virological …
Differential expression of Tim-3, PD-1, and CCR5 on peripheral T and B lymphocytes in hepatitis C virus-related hepatocellular carcinoma and their impact on …
Background and objective Activation of the immune checkpoints and expression of
chemokines and chemokine receptors have been reported to promote HCC progression …
chemokines and chemokine receptors have been reported to promote HCC progression …
Cutting edge: programmed death-1 expression is increased on immunocytes in chronic hepatitis C virus and predicts failure of response to antiviral therapy: race …
Up-regulation of programmed death-1 (PD-1) identifies exhausted T cells in various mouse
and human viral models including chronic hepatitis C virus (HCV) infection, which is …
and human viral models including chronic hepatitis C virus (HCV) infection, which is …