Eosinophil-guided corticosteroid therapy in patients admitted to hospital with COPD exacerbation (CORTICO-COP): a multicentre, randomised, controlled, open-label …

P Sivapalan, TS Lapperre, J Janner… - The Lancet …, 2019 - thelancet.com
Background Treatment with systemic corticosteroids in patients with acute exacerbations of
chronic obstructive pulmonary disease (COPD) is associated with debilitating adverse …

Treatment implications on morbidity and mortality in COPD

DW Mapel - Chest, 2004 - Elsevier
Inhaled corticosteroids (ICSs) remain controversial in COPD, although recent clinical trials
have consistently found that they reduce chronic respiratory symptoms and, in some …

Inhaled corticosteroids in COPD: a controversy

PJ Barnes - Respiration, 2010 - karger.com
Inhaled corticosteroids (ICS) are now very widely used in high doses in the management of
COPD patients. In sharp contrast to the situation in asthma, ICS provide little or no benefit in …

Practical Recommendations for a Selection of Inhaled Corticosteroids in COPD: A Composite ICO Chart

K Oishi, K Matsunaga, T Yamamoto, K Matsuda… - Biomolecules, 2023 - mdpi.com
The use of inhaled corticosteroids (ICS) for the maintenance of bronchodilator treatment in
patients with chronic obstructive pulmonary disease (COPD) is controversial. While some …

Withdrawal of inhaled corticosteroids versus continuation of triple therapy in patients with COPD in real life: observational comparative effectiveness study

H Magnussen, S Lucas, T Lapperre, JK Quint… - Respiratory …, 2021 - Springer
Background Inhaled corticosteroids (ICS) are indicated for prevention of exacerbations in
patients with COPD, but they are frequently overprescribed. ICS withdrawal has been …

[HTML][HTML] COPD treatment–a conceptual review based on critical endpoints

A Roque, L Taborda-Barata, ÁA Cruz, G Viegi… - Pulmonology, 2023 - Elsevier
Introduction Chronic obstructive pulmonary disease (COPD) is one of the main causes of
death and disability worldwide. Many treatment options are now available, but criteria for …

Association of inhaled corticosteroids with all-cause mortality risk in patients with COPD: a meta-analysis of 60 randomized controlled trials

H Chen, ZX Deng, J Sun, Q Huang, L Huang, YH He… - Chest, 2023 - Elsevier
Background Inhaled corticosteroids (ICSs) have been used widely in the maintenance
therapy of COPD. However, whether inhaled therapy containing ICSs can reduce the all …

What to use INSTEAD of inhaled corticosteroids in COPD?

PMA Calverley - European Respiratory Journal, 2014 - Eur Respiratory Soc
Inhaled corticosteroids (ICS) have had an important impact on the management of chronic
obstructive pulmonary disease (COPD). When combined with an inhaled long-acting b …

Inhaled corticosteroids vs placebo for preventing COPD exacerbations: a systematic review and metaregression of randomized controlled trials

R Agarwal, AN Aggarwal, D Gupta, SK Jindal - Chest, 2010 - Elsevier
Background Inhaled corticosteroids (ICS) have been shown to decrease the occurrence of
COPD exacerbations. However, the relationship of baseline lung function and reduction of …

The dose of inhaled corticosteroids in patients with COPD: when less is better

JL Izquierdo, BG Cosio - International Journal of Chronic …, 2018 - Taylor & Francis
Background The use of inhaled corticosteroids (ICS) in combination with bronchodilators in
patients with COPD has been shown to decrease the rate of disease exacerbations and to …