The immunoglobulin E (IgE) high-affinity receptor FcεRI expressed on mast cells and
basophils plays a critical role in triggering allergic disease. The co-aggregation of the FcεRI …

BACKGROUND: Coaggregating FcεRI with FcγRII receptors holds great potential for
treatment of IgE-mediated disease by inhibiting FcεRI signaling. We have previously shown …

Co-aggregation of FcεRI with FcγRIIb can block FcεRI-mediated reactivity and Fc gamma:
allergen chimeric proteins, by co-crosslinking FcγRIIb to allergen-specific IgE bound to the …

Allergic responses are strongly associated with Th2-type immune responses, and
modulation of the skewed Th2 response toward a more balanced response is the major goal …

Purpose High-affinity receptor I (FcεRI) on mast cells and basophils plays a key role in the
immunoglobulin E (IgE)-mediated type I hypersensitivity mediated by allergen cross-linking …

Background The blocking function of allergen-specific F (ab') 2 [sF (ab') 2] and Fab (sFab)
fragment antibodies prepared from allergen immunotherapy–induced specific …

Allergic asthma is characterized by airway eosinophilia, increased mucin production and
allergen-specific IgE. Fc gamma receptor IIb (FcγRIIb), an inhibitory IgG receptor, has …

Background: The interaction of immune complexes consisting of allergens and allergen–
specific IgE with the high–affinity Fcε receptor represents the key event in the induction of …

Background: IgE-dependent activation of mast cells and basophils through the high-affinity
IgE receptor (FcϵRI) is involved in the pathogenesis of allergen-induced immediate and late …

Recombinant Der f 2 (rDer f 2) is a promising new allergen expected to improve the
diagnosis and immunotherapy of house dust mite allergy and to further immunological …