Cannabis has been used recreationally and medically for centuries, yet research into
understanding the mechanisms of its therapeutic effects has only recently garnered more …

Considerable plasticity exists in the endogenous cannabinoid system, as evidenced by the
high degree of tolerance that develops following repetitive exposure to exogenously …

Molecular mechanisms regulating the development of physiological and behavioral
tolerance to cannabinoids are not well understood. Two cellular correlates implicated in the …

Marijuana produces a number of characteristic behaviors in humans and animals, including
memory impairment, antinociception, and locomotor and psychoactive effects. However …

The use of marijuana for recreational and medicinal purposes has resulted in a large
prevalence of chronic marijuana users. Consequences of chronic cannabinoid …

Receptor internalization increases the flexibility and scope of G protein-coupled receptor
(GPCR) signaling. CB1 and CB2 cannabinoid receptors undergo internalization after …

Agonists stimulate cannabinoid 1 receptor (CB1R) internalization. Previous work suggests
that the extreme carboxy‐terminus of the receptor regulates this internalization–likely …

Tolerance to compounds that target G protein–coupled receptors (GPCRs), such as the
cannabinoid type-1 receptor (CB1R), is in part facilitated by receptor desensitization …

The type 1 cannabinoid receptor (CB1 receptor) is considered to be the most abundant G
protein-coupled receptor (GPCR) in the mammalian brain. The presence and highly …

Chronic cannabinoid exposure results in tolerance due to region-specific desensitization
and down-regulation of CB1 cannabinoid receptors (CB1Rs). For most G-protein-coupled …