[HTML][HTML] Modeling extracellular matrix-cell interactions in lung repair and chronic disease

TL Hackett, ET Osei - Cells, 2021 - mdpi.com
The lung extracellular matrix (ECM) is a complex and dynamic mixture of fibrous proteins
(collagen, elastin), glycoproteins (fibronectin, laminin), glycosaminoglycans (heparin …

Extracellular matrix in lung development, homeostasis and disease

Y Zhou, JC Horowitz, A Naba, N Ambalavanan… - Matrix Biology, 2018 - Elsevier
The lung's unique extracellular matrix (ECM), while providing structural support for cells, is
critical in the regulation of developmental organogenesis, homeostasis and injury-repair …

Extracellular matrix as a driver of Chronic Lung diseases

JK Burgess, DJ Weiss… - American Journal of …, 2024 - atsjournals.org
The extracellular matrix (ECM) is not just a three-dimensional scaffold that provides stable
support for all cells in the lungs, but also an important component of chronic fibrotic airway …

Matrix remodeling in chronic lung diseases

BH Gu, MC Madison, D Corry, F Kheradmand - Matrix Biology, 2018 - Elsevier
Multicellular organisms synthesize and renew components of their subcellular and
scaffolding proteins, collectively known as the extracellular matrix molecules (ECMs). In the …

[HTML][HTML] Chronic lung diseases: entangled in extracellular matrix

JK Burgess, MC Harmsen - European Respiratory Review, 2022 - Eur Respiratory Soc
The extracellular matrix (ECM) is the scaffold that provides structure and support to all
organs, including the lung; however, it is also much more than this. The ECM provides …

[HTML][HTML] Extracellular matrix dynamics: tracking in biological systems and their implications

M Hu, Z Ling, X Ren - Journal of Biological Engineering, 2022 - Springer
The extracellular matrix (ECM) constitutes the main acellular microenvironment of cells in
almost all tissues and organs. The ECM not only provides mechanical support, but also …

[HTML][HTML] Extracellular matrix component remodeling in respiratory diseases: what has been found in clinical and experimental studies?

JT Ito, JD Lourenço, RF Righetti, IFLC Tibério… - Cells, 2019 - mdpi.com
Changes in extracellular matrix (ECM) components in the lungs are associated with the
progression of respiratory diseases, such as asthma, chronic obstructive pulmonary disease …

Lung extracellular matrix and fibroblast function

ES White - Annals of the American Thoracic Society, 2015 - atsjournals.org
Extracellular matrix (ECM) is a tissue-specific macromolecular structure that provides
physical support to tissues and is essential for normal organ function. In the lung, ECM plays …

The multi-faceted extracellular matrix: Unlocking its secrets for understanding the perpetuation of lung fibrosis

M Nizamoglu, JK Burgess - Current Tissue Microenvironment Reports, 2021 - Springer
Abstract Purpose of Review Lung fibrosis is currently thought to stem from an aberrant
wound healing response after recurring (micro) injuries in the lung epithelium, together with …

[HTML][HTML] Extracellular matrix as a driver of progressive fibrosis

J Herrera, CA Henke… - The Journal of clinical …, 2018 - Am Soc Clin Investig
The extracellular matrix (ECM) is dynamically tuned to optimize physiological function. Its
major properties, including composition and mechanics, profoundly influence cell biology …