Cancer Morbidity and mortality result from invasive and metastatic spread. Currently, no
therapies are aimed at the underlying mechanisms that enable this progression due to only …

Metastasis remains the greatest challenge in the clinical management of cancer. Cell motility
is a fundamental and ancient cellular behaviour that contributes to metastasis and is …

Advances in diagnosis and treatment have rendered most solid tumors largely curable if
they are diagnosed and treated before dissemination. However, once they spread beyond …

Cell migration is an essential systemic behavior, tightly regulated, of all living cells endowed
with directional motility that is involved in the major developmental stages of all complex …

Investigations across a range of disciplines over the past decade have brought the study of
cell motility and its role in invasion to an exciting threshold. The biophysical forces …

Due to the limited space we apologize that we cannot present a complete overview of all
motility factors and signaling pathways important for tumor invasion and metastasis. Instead …

Mortality and morbidity in patients with solid tumors invariably result from the disruption of
normal biological function caused by disseminating tumor cells. Tumor cell migration is …

Cancer cell migration and invasion are integral components of metastatic disease, which is
the major cause of death in cancer patients. Cancer cells can disseminate and migrate via …

Cell migration and invasion are critical parameters in the metastatic dissemination of cancer
cells and the formation of metastasis, the major cause of death in cancer patients. Migratory …

Invasion of neighboring extracellular matrix tissue, the lymphatic system and blood vessels
is a key element of tumor cell metastasis in many epithelial tumors. Understanding the cell …