The rostral ventromedial medulla (RVM) is a bulbospinal nuclei in the descending pain
modulation system, and directly affects spinal nociceptive transmission through …

The sensory experience of pain depends not only on the transmission of noxious information
(nociception), but on the state of the body in a biological, psychological, and social milieu. A …

The descending-pain modulating circuit controls the experience of pain by modulating
transmission of sensory signals through the dorsal horn. This circuit's key output node, the …

Spinal nociceptive processing is under the control of specific brainstem modulatory circuits.
The best studied and probably functionally most significant such modulatory circuit has links …

Complex networks of pathways project from various structures in the brain to modulate
spinal processing of sensory input in a top-down fashion. The rostral ventromedial medulla …

The brain is able to amplify or suppress nociceptive signals by means of descending
projections to the spinal and trigeminal dorsal horns from the rostral ventromedial medulla …

The rostral ventromedial medulla (RVM) has a well-documented role in pain modulation and
exerts antinociceptive and pronociceptive influences mediated by 2 distinct classes of …

The supraspinal descending pain modulatory system (DPMS) shapes pain perception via
monoaminergic modulation of sensory information in the spinal cord. However, the role and …

Descending input from the rostral ventromedial medulla (RVM) provides positive and
negative modulation of spinal nociceptive transmission and has been proposed to be critical …

Nerve injury can lead to mechanical hypersensitivity in both humans and animal models,
such that innocuous touch produces pain. Recent functional studies have demonstrated a …