In solid organ transplantation (Tx), both survival rates and quality of life have improved
dramatically over the last few decades. Each year, the number of people on the wait list …

Liver transplantation is an effective intervention for end-stage liver disease, fulminant
hepatic failure, and early hepatocellular carcinoma. Yet, there is marked patient-to-patient …

This review provides a summary of the applications and potential applications of metabolite
profiling (ie metabolomics) in monitoring organ transplants. While the concept of …

Organ transplantation is the treatment of choice for many end stage diseases. The
development and appropriate use of new immunosupressants have considerably improved …

Metabolomics enables the analysis of metabolites within an organism, which offers the
closest direct measurement of the physiological activity of the organism, and has advanced …

Background & Aims There is an emerging need to assess the metabolic state of liver
allografts especially in the novel setting of machine perfusion preservation and donor in …

Monitoring graft recipients remains dependent on traditional biomarkers and old
technologies lacking specificity, sensitivity, or accuracy. Recently, metabolomics is …

To improve the outcome of orthotopic liver transplantation (OLT), knowledge of early
molecular events occurring upon ischemia/reperfusion is essential. Powerful approaches for …

Although hypothermic machine perfusion (HMP) is associated with improved kidney graft
viability and function, the underlying biological mechanisms are unknown. Untargeted …

Background & Aims Early allograft dysfunction (EAD) dramatically influences graft and
patient outcome after orthotopic liver transplantation and its incidence is strongly determined …