In the pursuit of optimal anti-tumor immune effects, both “passive” and “active”
immunotherapies have made significant progress recently. In situ vaccines offer a promising …

Vaccination has had a tremendous impact on human health by harnessing the immune
system to prevent and eradicate infectious diseases and this same approach might be used …

After 100 years of debate, it is clear that cancer is recognized by the immune system and this
has generated immense interest in cancer immunotherapy. The systemic nature of the …

As cancer immunotherapy continues to benefit from novel approaches which cut immune
'brake pedals'(eg anti-PD1 and anti-CTLA4 antibodies) and push immune cell gas pedals …

After decades of development in the shadow of traditional cancer treatment, immunotherapy
has come into the spotlight. Treatment of metastatic tumors with monoclonal antibodies to T …

Prophylactic vaccinations have been one of the greatest advances in modern medicine, both
eradicating disease and reducing mortality. The translation of this advance into cancer …

The emergence of immune checkpoint inhibitors (ICIs) has revolutionized the clinical
treatment for tumor. However, the low response rate of ICIs remains the major obstacle for …

Despite advancements in our ability to diagnosis and treat cancer, cancer progression still
occurs in many patients. Disease progression at sites other than the treated tumor remains …

In situ vaccination is an emerging cancer treatment strategy that uses local therapies to
stimulate a systemic antitumor immune response. We previously reported an in situ …

Tumor microenvironment is known to play important roles in tumor progression. Many
therapies, targeting the tumor microenvironment, are designed and applied in the clinic. One …