Dysregulation of EZH2/miR‐138‐5p Axis Contributes to Radiosensitivity in Hepatocellular Carcinoma Cell by Downregulating Hypoxia‐Inducible Factor 1 Alpha (HIF …

B Bai, Y Liu, XM Fu, HY Qin, GK Li… - Oxidative Medicine …, 2022 - Wiley Online Library
Enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase involved in cell
proliferation, invasion, angiogenesis, and metastasis in various cancers, including …

EZH2 regulates cancer cell migration through repressing TIMP-3 in non-small cell lung cancer

C Xu, Z Hou, P Zhan, W Zhao, C Chang, J Zou, H Hu… - Medical oncology, 2013 - Springer
Histone methylations play important roles in human cancer metastasis. Enhancer of zeste
homolog 2 (EZH2) is a key component of the polycomb repressor complex 2, which is …

Proteomic analysis of EZH2 downstream target proteins in hepatocellular carcinoma

Y Chen, MC Lin, H Wang, C Chan, L Jiang… - …, 2007 - Wiley Online Library
Enhancer of zeste homolog 2 (EZH2) is suggested to be a potential therapeutic target and a
diagnostic marker for cancer. Our previous study also showed the critical role of EZH2 in …

Overexpression of EZH2 contributes to acquired cisplatin resistance in ovarian cancer cells in vitro and in vivo

S Hu, L Yu, Z Li, Y Shen, J Wang, J Cai… - Cancer biology & …, 2010 - Taylor & Francis
Enhancer of Zeste Homologue 2 (EZH2), a specific histone 3 lysine 27 (H3K27)
methyltransferase, plays a critical role in tumorigenesis and cancer progression through …

[HTML][HTML] EZH2 in cancer progression and potential application in cancer therapy: a friend or foe?

KS Yan, CY Lin, TW Liao, CM Peng, SC Lee… - International journal of …, 2017 - mdpi.com
Enhancer of zeste homolog 2 (EZH2), a histone methyltransferase, catalyzes tri-methylation
of histone H3 at Lys 27 (H3K27me3) to regulate gene expression through epigenetic …

[PDF][PDF] Enhancer of zeste homolog 2 epigenetically silences multiple tumor suppressor microRNAs to promote liver cancer metastasis

SLK Au, CCL Wong, JMF Lee, DNY Fan… - …, 2012 - Wiley Online Library
Epigenetic alterations and microRNA (miRNA) deregulation are common in hepatocellular
carcinoma (HCC). The histone H3 lysine 27 (H3K27) tri‐methylating enzyme, enhancer of …

[HTML][HTML] RNAi-mediated EZH2 depletion decreases MDR1 expression and sensitizes multidrug-resistant hepatocellular carcinoma cells to chemotherapy

B Tang, Y Zhang, R Liang, Z Gao… - Oncology …, 2013 - spandidos-publications.com
The histone-lysine N-methyltransferase, enhancer of zeste homologue 2 (EZH2), functions
as a transcriptional repressor and plays an important role in the development of various …

[HTML][HTML] EZH2-mediated epigenetic silencing of TIMP2 promotes ovarian cancer migration and invasion

X Yi, J Guo, J Guo, S Sun, P Yang, J Wang, Y Li… - Scientific reports, 2017 - nature.com
Enhancer of zeste homolog 2 (EZH2) is often increased in malignant tumors and is involved
in metastasis. EZH2 silences gene expression by tri-methylating the lysine 27 residue of …

EZH2 promotes invasion and metastasis of laryngeal squamous cells carcinoma via epithelial-mesenchymal transition through H3K27me3

HN Luo, Y Jiang, SJ Ma, HH Chang, CX Yi… - Biochemical and …, 2016 - Elsevier
Abstract Enhancer of Zeste Homolog 2 (EZH2), which can change chromatin structure by tri-
methylation of the 27th lysine of H3 in nucleosome histone (H3K27me3), is involved in …

[HTML][HTML] EZH2 regulates oncomiR-200c and EMT markers in esophageal squamous cell carcinomas

F Nourmohammadi, MM Forghanifard… - Scientific Reports, 2022 - nature.com
EZH2, as a histone methyltransferase, has been associated with cancer development and
metastasis possibly through the regulation of microRNAs and cellular pathways such as …