[HTML][HTML] The CCR5 antagonist maraviroc exerts limited neuroprotection without improving neurofunctional outcome in experimental pneumococcal meningitis
ND Le, M Steinfort, D Grandgirard, A Maleska… - Scientific reports, 2022 - nature.com
One-third of pneumococcal meningitis (PM) survivors suffer from neurological sequelae
including learning disabilities and hearing loss due to excessive neuroinflammation. There …
including learning disabilities and hearing loss due to excessive neuroinflammation. There …
Reparixin attenuates neuronal injury in experimental Klebsiella pneumoniae meningoencephalitis through dual effects on neuroprotection and neuroinflammation
CT Chiu, LL Wen, HP Pao, LY Yang… - Neuropathology and …, 2016 - Wiley Online Library
Aims Bacterial meningitis causes high mortality and brain damage. The host immune
response is associated with brain injury. Chemokine (C‐X‐C motif)(CXC) chemokines are …
response is associated with brain injury. Chemokine (C‐X‐C motif)(CXC) chemokines are …
[HTML][HTML] Adjuvant cannabinoid receptor type 2 agonist modulates the polarization of microglia towards a non-inflammatory phenotype in experimental pneumococcal …
SD Pan, D Grandgirard, SL Leib - Frontiers in cellular and infection …, 2020 - frontiersin.org
Background Microglia initiates and sustains the inflammatory reaction that drives the
pathogenesis of pneumococcal meningitis. The expression of the G-protein cannabinoid …
pathogenesis of pneumococcal meningitis. The expression of the G-protein cannabinoid …
[HTML][HTML] Combining antibiotic with anti-TLR2/TLR13 therapy prevents brain pathology in pneumococcal meningitis
S Dyckhoff-Shen, I Masouris, H Islam… - JCI insight, 2024 - ncbi.nlm.nih.gov
Despite effective antibiotic therapy, brain-destructive inflammation often cannot be avoided
in pneumococcal meningitis. The causative signals are mediated predominantly through …
in pneumococcal meningitis. The causative signals are mediated predominantly through …
[HTML][HTML] The matrix metalloproteinase inhibitor RS-130830 attenuates brain injury in experimental pneumococcal meningitis
FD Liechti, F Bächtold, D Grandgirard… - Journal of …, 2015 - Springer
Background Pneumococcal meningitis (PM) is characterized by high mortality and morbidity
including long-term neurofunctional deficits. Neuropathological correlates of these sequelae …
including long-term neurofunctional deficits. Neuropathological correlates of these sequelae …
[HTML][HTML] Adjuvant TACE inhibitor treatment improves the outcome of TLR2-/-mice with experimental pneumococcal meningitis
H Echchannaoui, SL Leib, U Neumann… - BMC infectious …, 2007 - Springer
Background Streptococcus (S.) pneumoniae meningitis has a high lethality despite antibiotic
treatment. Inflammation is a major pathogenetic factor, which is unresponsive to antibiotics …
treatment. Inflammation is a major pathogenetic factor, which is unresponsive to antibiotics …
Combining ceftriaxone with doxycycline and daptomycin reduces mortality, neuroinflammation, brain damage, and hearing loss in infant rat pneumococcal meningitis
L Muri, M Perny, J Zemp, D Grandgirard… - Antimicrobial agents …, 2019 - Am Soc Microbiol
Despite appropriate antibiotic therapy, pneumococcal meningitis (PM) is associated with a
case fatality rate of up to 30% in high-income countries. Survivors often suffer from severe …
case fatality rate of up to 30% in high-income countries. Survivors often suffer from severe …
[HTML][HTML] Combined effect of non-bacteriolytic antibiotic and inhibition of matrix metalloproteinases prevents brain injury and preserves learning, memory and hearing …
L Muri, D Grandgirard, M Buri, M Perny… - Journal of …, 2018 - Springer
Background Pneumococcal meningitis is associated with high mortality and morbidity rates.
Up to 50% of survivors show neurologic sequelae including hearing loss, cognitive …
Up to 50% of survivors show neurologic sequelae including hearing loss, cognitive …
Inhibition of matrix metalloproteinases and tumour necrosis factor α converting enzyme as adjuvant therapy in pneumococcal meningitis
SL Leib, JM Clements, RLP Lindberg, C Heimgartner… - Brain, 2001 - academic.oup.com
Matrix metalloproteinases (MMPs) and tumour necrosis factor α (TNF-α) converting enzyme
(TACE) contribute synergistically to the pathophysiology of bacterial meningitis. TACE …
(TACE) contribute synergistically to the pathophysiology of bacterial meningitis. TACE …
Neuroprotection by a caspase inhibitor in acute bacterial meningitis
JS Braun, R Novak, KH Herzog, SM Bodner… - Nature medicine, 1999 - nature.com
Half of the survivors of bacterial meningitis experience motor deficits, seizures, hearing loss
or cognitive impairment, despite adequate bacterial killing by antibiotics. We demonstrate …
or cognitive impairment, despite adequate bacterial killing by antibiotics. We demonstrate …