Potential benefits of medium chain fatty acids in aging and neurodegenerative disease

E Dunn, B Zhang, VK Sahota… - Frontiers in Aging …, 2023 - frontiersin.org
Neurodegenerative diseases are a large class of neurological disorders characterized by
progressive dysfunction and death of neurones. Examples include Alzheimer's disease …

Medium-chain fatty acids for the prevention or treatment of Alzheimer's disease: a systematic review and meta-analysis

CB Castro, CB Dias, H Hillebrandt, HR Sohrabi… - Nutrition …, 2023 - academic.oup.com
Abstract Context In preclinical Alzheimer's disease (AD), the brain gradually becomes
insulin resistant. As a result, brain glucose utilization is compromised, causing a cellular …

Fats, friends or foes: investigating the role of short-and medium-chain fatty acids in Alzheimer's disease

AO Ameen, K Freude, BI Aldana - Biomedicines, 2022 - mdpi.com
Characterising Alzheimer's disease (AD) as a metabolic disorder of the brain is gaining
acceptance based on the pathophysiological commonalities between AD and major …

Short-chain fatty acids in the context of Parkinson's disease

J Metzdorf, L Tönges - Neural Regeneration Research, 2021 - journals.lww.com
Research on neurodegenerative diseases such as Alzheimer's disease, Parkinsons disease
(PD), Huntington's disease or amyotrophic lateral sclerosis is becoming increasingly …

How can a ketogenic diet improve motor function?

C Veyrat-Durebex, P Reynier, V Procaccio… - Frontiers in molecular …, 2018 - frontiersin.org
A ketogenic diet (KD) is a normocaloric diet composed by high fat (80–90%), low
carbohydrate, and low protein consumption that induces fasting-like effects. KD increases …

The impact of medium chain and polyunsaturated ω-3-fatty acids on amyloid-β deposition, oxidative stress and metabolic dysfunction associated with Alzheimer's …

J Mett - Antioxidants, 2021 - mdpi.com
Alzheimer's disease (AD), the most common cause of dementia in the elderly population, is
closely linked to a dysregulated cerebral lipid homeostasis and particular changes in brain …

Are ketogenic diets promising for Alzheimer's disease? A translational review

M Lilamand, B Porte, E Cognat, J Hugon… - Alzheimer's research & …, 2020 - Springer
Background Brain amyloid deposition and neurofibrillary tangles in Alzheimer's disease
(AD) are associated with complex neuroinflammatory reactions such as microglial activation …

Ketogenic diets: an historical antiepileptic therapy with promising potentialities for the aging brain

M Balietti, T Casoli, G Di Stefano, B Giorgetti… - Ageing research …, 2010 - Elsevier
Ketogenic diets (KDs), successfully used in the therapy of paediatric epilepsy for nearly a
century, have recently shown beneficial effects also in cancer, obesity, diabetes, GLUT 1 …

Decanoic acid and not octanoic acid stimulates fatty acid synthesis in U87MG glioblastoma cells: a metabolomics study

F Damiano, GE De Benedetto, S Longo… - Frontiers in …, 2020 - frontiersin.org
Medium-chain fatty acids (MCFA) are dietary components with a chain length ranging from 6
to 12 carbon atoms. MCFA can cross the blood-brain barrier and in the brain can be …

Western and ketogenic diets in neurological disorders: can you tell the difference?

KJ Habashy, F Ahmad, S Ibeh, S Mantash… - Nutrition …, 2022 - academic.oup.com
The prevalence of obesity tripled worldwide between 1975 and 2016, and it is projected that
half of the US population will be overweight by 2030. The obesity pandemic is attributed, in …