Simple Summary The potential importance of germline genetic variation for identifying men
at increased risk of prostate cancer has become increasingly recognised in recent years. We …

Improvements in DNA sequencing technology and discoveries made by large scale genome-
wide association studies have led to enormous insight into the role of genetic variation in …

Most criteria for genetic testing for prostate cancer susceptibility require a prior diagnosis of
prostate cancer, in particular cases with metastatic disease are selected. Advances in the …

The inherited link of prostate cancer predisposition has been supported using data from
early epidemiological studies, as well as from familial and twin studies. Early linkage …

Prostate cancer is the second most common malignancy affecting men worldwide, and the
commonest affecting men of African descent. Significant diagnostic and therapeutic …

Few genetic risk factors have been demonstrated to be specifically associated with
aggressive prostate cancer (PrCa). Here, we report a case‐case study of PrCa comparing …

BACKGROUND One of the difficulties confronting genetic studies of prostate cancer is the
complex and heterogeneous etiology. Given the high population frequency of lesions …

BACKGROUND Prostate cancer (PCa) remains the most common solid malignancy in men,
and its prevalence makes understanding its heritability of paramount importance. To date …

Worldwide, familial and epidemiological studies have generated considerable evidence of
an inherited component to prostate cancer. Indeed, rare highly penetrant genetic mutations …

Simple Summary Advances in our understanding of the molecular basis of prostate cancer
have resulted in the discovery of a subset of patients harboring germline variants that places …