Identification of germline genetic variants that increase prostate cancer risk and influence development of aggressive disease
EJ Saunders, Z Kote-Jarai, RA Eeles - Cancers, 2021 - mdpi.com
Simple Summary The potential importance of germline genetic variation for identifying men
at increased risk of prostate cancer has become increasingly recognised in recent years. We …
at increased risk of prostate cancer has become increasingly recognised in recent years. We …
Genetic predisposition to prostate cancer: an update
H Ni Raghallaigh, R Eeles - Familial Cancer, 2022 - Springer
Improvements in DNA sequencing technology and discoveries made by large scale genome-
wide association studies have led to enormous insight into the role of genetic variation in …
wide association studies have led to enormous insight into the role of genetic variation in …
An appraisal of genetic testing for prostate cancer susceptibility
Most criteria for genetic testing for prostate cancer susceptibility require a prior diagnosis of
prostate cancer, in particular cases with metastatic disease are selected. Advances in the …
prostate cancer, in particular cases with metastatic disease are selected. Advances in the …
Germline genetic variants associated with prostate cancer and potential relevance to clinical practice
CL Goh, RA Eeles - Prostate cancer prevention, 2014 - Springer
The inherited link of prostate cancer predisposition has been supported using data from
early epidemiological studies, as well as from familial and twin studies. Early linkage …
early epidemiological studies, as well as from familial and twin studies. Early linkage …
[HTML][HTML] Men with a susceptibility to prostate cancer and the role of genetic based screening
R Eeles, HN Raghallaigh - Translational andrology and urology, 2018 - ncbi.nlm.nih.gov
Prostate cancer is the second most common malignancy affecting men worldwide, and the
commonest affecting men of African descent. Significant diagnostic and therapeutic …
commonest affecting men of African descent. Significant diagnostic and therapeutic …
Rare germline genetic variants and risk of aggressive prostate cancer
T Nguyen‐Dumont, RJ MacInnis… - … journal of cancer, 2020 - Wiley Online Library
Few genetic risk factors have been demonstrated to be specifically associated with
aggressive prostate cancer (PrCa). Here, we report a case‐case study of PrCa comparing …
aggressive prostate cancer (PrCa). Here, we report a case‐case study of PrCa comparing …
Genome‐wide screen for prostate cancer susceptibility genes in men with clinically significant disease
BL Chang, SD Isaacs, KE Wiley, EM Gillanders… - The …, 2005 - Wiley Online Library
BACKGROUND One of the difficulties confronting genetic studies of prostate cancer is the
complex and heterogeneous etiology. Given the high population frequency of lesions …
complex and heterogeneous etiology. Given the high population frequency of lesions …
Germline genetics of prostate cancer: time to incorporate genetics into early detection tools
RJ Fantus, BT Helfand - Clinical Chemistry, 2019 - academic.oup.com
BACKGROUND Prostate cancer (PCa) remains the most common solid malignancy in men,
and its prevalence makes understanding its heritability of paramount importance. To date …
and its prevalence makes understanding its heritability of paramount importance. To date …
The genetic epidemiology of prostate cancer and its clinical implications
R Eeles, C Goh, E Castro, E Bancroft, M Guy… - Nature reviews …, 2014 - nature.com
Worldwide, familial and epidemiological studies have generated considerable evidence of
an inherited component to prostate cancer. Indeed, rare highly penetrant genetic mutations …
an inherited component to prostate cancer. Indeed, rare highly penetrant genetic mutations …
Germline genetics of prostate cancer: prevalence of risk variants and clinical implications for disease management
DK Doan, KT Schmidt, CH Chau, WD Figg - Cancers, 2021 - mdpi.com
Simple Summary Advances in our understanding of the molecular basis of prostate cancer
have resulted in the discovery of a subset of patients harboring germline variants that places …
have resulted in the discovery of a subset of patients harboring germline variants that places …
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