Immune correlates of hepatitis C virus (HCV) clearance and control remain poorly defined
due to the lack of an informative animal model. We recently described acute and chronic …

Immune-competent animal models for the hepatitis C virus (HCV) are nonexistent, impeding
studies of host-virus interactions and vaccine development. Experimental infection of …

Evidence assessing the role of B cells and their antibodies, or lack thereof, in the
spontaneous resolution of hepatitis C virus (HCV) infection is conflicting. Utilization of a …

Hepatitis C virus (HCV) has a high propensity for persistence. To better define the
immunologic determinants of HCV clearance and persistence, we examined the circulating …

Introduction: Despite advancements in hepatitis C virus (HCV) infection treatment, HCV still
represents a significant public health burden. Besides progressive hepatic damage, viral …

The differentiation and functional status of virus-specific CD8+ T cells is significantly
influenced by specific and ongoing antigen recognition. Importantly, the expression profiles …

Virus-specific CD8+ T cells are rarely detectable ex vivo by conventional methods during
chronic hepatitis C virus (HCV) infection. In this study, however, we were able to detect and …

Vigorous proliferative CD4+ T cell responses are the hallmark of spontaneous clearance of
acute hepatitis C virus (HCV) infection, whereas comparable responses are absent in …

CD4+ T cell failure is a hallmark of chronic hepatitis C virus (HCV) infection. However, the
mechanisms underlying the impairment and loss of virus-specific CD4+ T cells in persisting …

Virus-specific CTL with high levels of functional avidity have been associated with viral
clearance in hepatitis C virus (HCV) infection and with enhanced protective immunity. In …